Role of the IgM Fc Receptor in Immunity and Tolerance

被引：71
作者：
Liu, Jun [1 ]
Wang, Ying [1 ]
Xiong, Ermeng [1 ]
Hong, Rongjian [1 ]
Lu, Qing [1 ]
Ohno, Hiroshi [2 ]
Wang, Ji-Yang [1 ]
机构：
[1] Fudan Univ, Sch Basic Med Sci, Dept Immunol, Shanghai, Peoples R China
[2] RIKEN, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan
来源：
FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷
基金：
中国国家自然科学基金; 日本学术振兴会;
关键词：
IgM; Fc mu R; BCR signal; humoral immune response; complement; B-CELL RECEPTOR; MU-R; ANTIBODY-RESPONSES; DENDRITIC CELLS; ALPHA/MU-R; TOSO; EXPRESSION; ACTIVATION; CDNA; TOSO/FAIM3;
D O I：
10.3389/fimmu.2019.00529
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immunoglobulin (Ig) M is the first antibody isotype to appear during evolution, ontogeny and immune responses. IgM not only serves as the first line of host defense against infections but also plays an important role in immune regulation and immunological tolerance. For many years, IgM is thought to function by binding to antigen and activating complement system. With the discovery of the IgMFc receptor (Fc mu R), it is now clear that IgM can also elicit its function through Fc mu R. In this review, we will describe the molecular characteristics of Fc mu R, its role in B cell development, maturation and activation, humoral immune responses, host defense, and immunological tolerance. We will also discuss the functional relationship between IgM-complement and IgM-Fc mu R pathways in regulating immunity and tolerance. Finally, we will discuss the potential involvement of Fc mu R in human diseases.
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页数：9
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共 66 条
  • [1] Cutting edge: Selection of B lymphocyte subsets is regulated by natural IgM
    Baker, N
    Ehrenstein, MR
    [J]. JOURNAL OF IMMUNOLOGY, 2002, 169 (12) : 6686 - 6690
  • [2] BOYDEN STEPHEN V., 1966, ADVANCE IMMUNOL, V5, P1, DOI 10.1016/S0065-2776(08)60271-0
  • [3] Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells
    Brenner, Dirk
    Bruestle, Anne
    Lin, Gloria H. Y.
    Lang, Philipp A.
    Duncan, Gordon S.
    Knobbe-Thomsen, Christiane B.
    Paul, Michael St.
    Reardon, Colin
    Tusche, Michael W.
    Snow, Bryan
    Hamilton, Sara R.
    Pfefferle, Aline
    Gilani, Syed O.
    Ohashi, Pamela S.
    Lang, Karl S.
    Mak, Tak W.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (03) : 1060 - 1065
  • [4] BURNS GF, 1979, IMMUNOLOGY, V36, P569
  • [5] Mouse IgM Fc Receptor, FCMR, Promotes B Cell Development and Modulates Antigen-Driven Immune Responses
    Choi, Seung-Chul
    Wang, Hongsheng
    Tian, Linjie
    Murakami, Yousuke
    Shin, Dong-Mi
    Borrego, Francisco
    Morse, Herbert C., III
    Coligan, John E.
    [J]. JOURNAL OF IMMUNOLOGY, 2013, 190 (03) : 987 - 996
  • [6] TOSO promotes β-cell proliferation and protects from apoptosis
    Dharmadhikari, G.
    Muehle, M.
    Schulthess, F. T.
    Laue, S.
    Oberholzer, J.
    Pattou, F.
    Kerr-Conte, J.
    Maedler, K.
    [J]. MOLECULAR METABOLISM, 2012, 1 (1-2): : 70 - 78
  • [7] Complement-Activating IgM Enhances the Humoral but Not the T Cell Immune Response in Mice
    Ding, Zhoujie
    Bergman, Anna
    Rutemark, Christian
    Ouchida, Rika
    Ohno, Hiroshi
    Wang, Ji-Yang
    Heyman, Birgitta
    [J]. PLOS ONE, 2013, 8 (11):
  • [8] Antibodies and B cell memory in viral immunity
    Doerner, Thomas
    Radbruch, Andreas
    [J]. IMMUNITY, 2007, 27 (03) : 384 - 392
  • [9] The importance of natural IgM: scavenger, protector and regulator
    Ehrenstein, Michael R.
    Notley, Clare A.
    [J]. NATURE REVIEWS IMMUNOLOGY, 2010, 10 (11) : 778 - 786
  • [10] The signaling tool box for tyrosine-based costimulation of lymphocytes
    Engels, Niklas
    Wienands, Juergen
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2011, 23 (03) : 324 - 329
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