Optical glucose monitoring based on femtosecond two-color pulse interferometry

We demonstrate the potential of femtosecond two-color pulse interferometry for in vitro optical glucose monitoring, by dispersion of the group refractive index ill a glucose Solution sample with respect to a red-color light and a blue-color light. By comparison with femtosecond one-color pulse interferometry, the basic performance of the present system with regard to sensitivity, quantitativeness, and tolerance to surrounding disturbances, is evaluated. The resulting accuracy and precision of glucose determination are 77 and 118 mg/dl for 10-mm-sample-thickness, respectively. This near-common-path configuration of the two-color Pulse light provides good stability to fluctuations of sample temperature, which is important in clinical applications. Considering the performance of femtosecond two-color Pulse interferometry as in optical glucose sensor, a Suitable measurement site for in vivo Optical glucose monitoring is discussed. (c) 2006 The Optical Society of Japan