Maintenance vs. Manipulation in Auditory Verbal Working Memory in the Elderly: New Insights Based on Temporal Dynamics of Information Processing in the Millisecond Time Range

被引:18
作者
Jablonska, Katarzyna [1 ]
Piotrowska, Magdalena [2 ]
Bednarek, Hanna [1 ]
Szymaszek, Aneta [2 ]
Marchewka, Artur [3 ]
Wypych, Marek [3 ]
Szelag, Elzbieta [2 ]
机构
[1] SWPS Univ Social Sci & Humanities, Fac Psychol, Warsaw, Poland
[2] Polish Acad Sci, Nencki Inst Expt Biol, Lab Neuropsychol, Warsaw, Poland
[3] Polish Acad Sci, Nencki Inst Expt Biol, Lab Brain Imaging, Warsaw, Poland
关键词
working memory; temporal information processing; auditoryn-back task; fMRI; maintenance and manipulation processes; N-BACK TASK; NEURAL BASIS; BRAIN ACTIVATION; FRONTAL-CORTEX; ORDER JUDGMENT; SHORT-TERM; PERCEPTION; AGE; COMPONENTS; INTERVAL;
D O I
10.3389/fnagi.2020.00194
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Working memory (WM) is a limited-capacity cognitive system that allows the storage and use of a limited amount of information for a short period of time. Two WM processes can be distinguished: maintenance (i.e., storing, monitoring, and matching information) and manipulation (i.e., reordering and updating information). A number of studies have reported an age-related decline in WM, but the mechanisms underlying this deterioration need to be investigated. Previous research, including studies conducted in our laboratory, revealed that age-related cognitive deficits are related to decreased millisecond timing, i.e., the ability to perceive and organize incoming events in time. The aim of the current study was: (1) to identify in the elderly the brain network involved in the maintenance and manipulation WM processes; and (2) to use an fMRI task to investigate the relation between the brain activity associated with these two processes and the efficiency of temporal information processing (TIP) on a millisecond level reflected by psychophysical indices. Subjects were 41 normal healthy elderly people aged from 62 to 78 years. They performed: (1) an auditory verbaln-back task for assessing WM efficiency in an MRI scanner; and (2) a psychophysical auditory temporal-order judgment (TOJ) task for assessing temporal resolution in the millisecond domain outside the scanner. Then-backtask comprised three conditions (0-, 1-, and 2-back), which allowed maintenance (1- vs. 0-back comparisons) and manipulation (2- vs. 1-back comparisons) processes to be distinguished. Results revealed the involvement of a similar brain network in the elderly to that found in previous studies. However, during maintenance processes, we found relatively limited and focused activations, which were significantly extended during manipulation. A novel result of our study, never reported before, is an indication of significant moderate correlations between the efficiency of WM and TIP. These correlations were found only for manipulation but not for maintenance. Our results confirmed the hypothesis that manipulation in the elderly is a dynamic process requiring skilled millisecond timing with high temporal resolution. We conclude that millisecond timing contributes to WM manipulation in the elderly, but not to maintenance.
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页数:17
相关论文
共 108 条
[1]   Pathophysiological distortions in time perception and timed performance [J].
Allman, Melissa J. ;
Meck, Warren H. .
BRAIN, 2012, 135 :656-677
[2]  
American National Standards Institute (ANSI), 2004, ANSI S3.6-2004
[3]   Dissociation of storage and rehearsal in verbal working memory: Evidence from positron emission tomography [J].
Awh, E ;
Jonides, J ;
Smith, EE ;
Schumacher, EH ;
Koeppe, RA ;
Katz, S .
PSYCHOLOGICAL SCIENCE, 1996, 7 (01) :25-31
[4]   The episodic buffer: a new component of working memory? [J].
Baddeley, A .
TRENDS IN COGNITIVE SCIENCES, 2000, 4 (11) :417-423
[5]  
Bao Y, 2014, ACTA NEUROBIOL EXP, V74, P98, DOI 10.55782/ane-2014-1976
[6]   Temporal order perception of auditory stimuli is selectively modified by tonal and non-tonal language environments [J].
Bao, Yan ;
Szymaszek, Aneta ;
Wang, Xiaoying ;
Oron, Anna ;
Poeppel, Ernst ;
Szelag, Elzbieta .
COGNITION, 2013, 129 (03) :579-585
[7]   Dorsolateral prefrontal contributions to human working memory [J].
Barbey, Aron K. ;
Koenigs, Michael ;
Grafman, Jordan .
CORTEX, 2013, 49 (05) :1195-1205
[8]   Cerebellar contributions to verbal working memory: beyond cognitive theory [J].
Ben-Yehudah, Gal ;
Guediche, Sara ;
Fiez, Julie A. .
CEREBELLUM, 2007, 6 (03) :193-201
[9]   Pre-stimulus beta oscillations within left posterior sylvian regions impact auditory temporal order judgment accuracy [J].
Bernasconi, Fosco ;
Manuel, Aurelie L. ;
Murray, Micah M. ;
Spierer, Lucas .
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 2011, 79 (02) :244-248
[10]   Interhemispheric coupling between the posterior sylvian regions impacts successful auditory temporal order judgment [J].
Bernasconi, Fosco ;
Grivel, Jeremy ;
Murray, Micah M. ;
Spierer, Lucas .
NEUROPSYCHOLOGIA, 2010, 48 (09) :2579-2585