miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells

被引：151

作者：

Li, Jipeng ^{[2
]}

Wang, Yiping ^{[2
]}

Luo, Jianping ^{[2
]}

Fu, Zhongming ^{[1
]}

Ying, Jianfei ^{[2
]}

Yu, Yanhong ^{[2
]}

Yu, Wanjun ^{[1
,2
]}

机构：

[1] Yinzhou Peoples Hosp, Dept Resp Dis, Ningbo 315040, Zhejiang, Peoples R China

[2] Yinzhou Peoples Hosp, Dept Clin Lab, Ningbo 315040, Zhejiang, Peoples R China

来源：

FEBS LETTERS | 2012年 / 586卷 / 20期

关键词：

miR-134; Epithelial-to-mesenchymal transition (EMT); NSCLC; FOXM1; TGF-beta; 1; M1 TRANSCRIPTION FACTOR; EXPRESSION; GROWTH; FAMILY; MECHANISMS; INVASION; LEADS;

D O I：

10.1016/j.febslet.2012.09.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have implied that miRNAs act as crucial modulators for epithelial-to-mesenchymal transition (EMT). We found that miR-134 expression correlated with invasive potential and EMT phenotype of NSCLC cells. Functional assays demonstrated that miR-134 inhibited EMT in NSCLC cells. In addition, we showed that Forkhead Box M1 (FOXM1) is a direct target of miR-134. Knockdown of FOXM1 reversed EMT resembling that of miR-134 overexpression. We further found that FOXM1 was involved in TGF-beta 1-induced EMT in A549 cells. These findings suggest that miR-134 acts as a novel EMT suppressor in NSCLC cells. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3761 / 3765

页数：5

共 29 条

[21] miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes [J].

Liu, Qin ;

Fu, Hanjiang ;

Sun, Fang ;

Zhang, Haoming ;

Tie, Yi ;

Zhu, Jie ;

Xing, Ruiyun ;

Sun, Zhixian ;

Zheng, Xiaofei .

NUCLEIC ACIDS RESEARCH, 2008, 36 (16) :5391-5404

[22] Mechanisms of TGF-β signaling in regulation of cell growth and differentiation [J].

Moustakas, A ;

Pardali, K ;

Gaal, A ;

Heldin, CH .

IMMUNOLOGY LETTERS, 2002, 82 (1-2) :85-91

[23] Metastasis: new perspectives on an old problem [J].

Pavelic, Sandra Kraljevic ;

Sedic, Mirela ;

Bosnjak, Hrvojka ;

Spaventi, Sime ;

Pavelic, Kresimir .

MOLECULAR CANCER, 2011, 10

[24] Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data [J].

Pilarsky, C ;

Wenzig, M ;

Specht, T ;

Saeger, HD ;

Grützmann, R .

NEOPLASIA, 2004, 6 (06) :744-750

[25] Effects of 1α,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells [J].

Wang, Wei-Lin W. ;

Chatterjee, Namita ;

Chittur, Sridar V. ;

Welsh, JoEllen ;

Tenniswood, Martin P. .

MOLECULAR CANCER, 2011, 10

[26] RETRACTED: Down-regulation of Forkhead Box M1 transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cells (Retracted article. See vol. 78, pg. 5470, 2018) [J].

Wang, Zhiwei ;

Banerjee, Sanjeev ;

Kong, Dejuan ;

Li, Yiwei ;

Sarkar, Fazlul H. .

CANCER RESEARCH, 2007, 67 (17) :8293-8300

[27] Forkhead box M1 transcription factor: A novel target for cancer therapy [J].

Wang, Zhiwei ;

Ahmad, Aamir ;

Li, Yiwei ;

Banerjee, Sanjeev ;

Kong, Dejuan ;

Sarkar, Fazlul H. .

CANCER TREATMENT REVIEWS, 2010, 36 (02) :151-156

[28] MicroRNA-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism [J].

Xiao, Junjie ;

Jing, Zhi-Cheng ;

Ellinor, Patrick T. ;

Liang, Dandan ;

Zhang, Hong ;

Liu, Ying ;

Chen, Xiaoli ;

Pan, Lei ;

Lyon, Robert ;

Liu, Yi ;

Peng, Lu-Ying ;

Liang, Xingqun ;

Sun, Yunfu ;

Popescu, Laurentiu M. ;

Condorelli, Gianluigi ;

Chen, Yi-Han .

JOURNAL OF TRANSLATIONAL MEDICINE, 2011, 9

[29] Transforming growth factor-β1 promotes lung adenocarcinoma invasion and metastasis by epithelial-to-mesenchymal transition [J].

Zhang, Hui-Jun ;

Wang, He-Yong ;

Zhang, Hong-Tao ;

Su, Jin-Mei ;

Zhu, Jun ;

Wang, Hai-Bing ;

Zhou, Wen-Yong ;

Zhang, Hui ;

Zhao, Ming-Chuan ;

Zhang, Lei ;

Chen, Xiao-Feng .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2011, 355 (1-2) :309-314

← 1 2 3 →