REG1A Expression is an Independent Factor Predictive of Poor Prognosis in Patients with Breast Cancer

被引:27
作者
Sasaki, Yasuhiro [1 ]
Minamiya, Yoshihiro [1 ]
Takahashi, Naoko [1 ]
Nakagawa, Taku [1 ]
Katayose, Yoshihisa [1 ]
Ito, Aki [1 ]
Saito, Hajime [1 ]
Motoyama, Satoru [1 ]
Ogawa, Jun-ichi [1 ]
机构
[1] Akita Univ, Sch Med, Dept Surg, Akita 0108543, Japan
基金
英国科研创新办公室;
关键词
D O I
10.1245/s10434-008-0137-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Regenerating gene I alpha (REG1A) is a growth factor known to affect pancreatic islet beta cells. Although REG1A expression has also been observed in various malignant tumors, the correlation between REG1A expression and the clinicopathological characteristics of breast cancer and patient prognosis has not been evaluated. Methods: Resected breast cancer tissues obtained at surgery from 150 breast cancer patients was stained with anti-REG1A antibody, after which the relative area occupied by stained tumor cells was evaluated under a light microscope and correlated with known clinicopathological factors. Results: Whereas tumor cells were frequently stained with anti-REG1A antibody, cells from normal breast tissue were not stained. REG1A expression in tumors of breast cancer patients with HER2-positive disease was higher than those with HER2-negative disease (P = .0009). The 10-year disease-specific survival rate among patients with lower levels of REG1A was significantly better than among those with higher levels (P = .0002 by log rank test). Multivariate Cox proportional hazard analyses revealed REG1A (hazard ratio, 2.07; 95% confidence interval, 1.93 to 11.29; P = .0005) and axillary lymph node status (hazard ratio, 4.44; 95% confidence interval, 1.52 to 11.29; P = .0003) to be independent factors affecting the 10-year disease-specific survival rate. Conclusion: High levels of REG1A expression within tumors are an independent predictor of poor prognosis in patients with breast cancer.
引用
收藏
页码:3244 / 3251
页数:8
相关论文
共 27 条
  • [1] Endocrine-responsive breast cancer and strategies for combating resistance
    Ali, S
    Coombes, RC
    [J]. NATURE REVIEWS CANCER, 2002, 2 (02) : 101 - +
  • [2] Broekaert D, 2002, EUR CYTOKINE NETW, V13, P78
  • [3] Overexpression of regenerating islet-derived 1 alpha and 3 alpha genes in human primaryliver tumors with β-catenin mutations
    Cavard, C
    Terris, B
    Grimber, G
    Christa, L
    Audard, V
    Bussiere, BR
    Simon, MT
    Renard, CA
    Buendia, MA
    Perret, C
    [J]. ONCOGENE, 2006, 25 (04) : 599 - 608
  • [4] Dissemination and growth of cancer cells in metastatic sites
    Chambers, AF
    Groom, AC
    MacDonald, IC
    [J]. NATURE REVIEWS CANCER, 2002, 2 (08) : 563 - 572
  • [5] Expression of regenerating gene I in gastric adenocarcinomas - Correlation with tumor differentiation status and patient survival
    Dhar, DK
    Udagawa, J
    Ishihara, S
    Otani, H
    Kinoshita, Y
    Takasawa, S
    Okamoto, H
    Kubota, H
    Fujii, T
    Tachibana, M
    Nagasue, N
    [J]. CANCER, 2004, 100 (06) : 1130 - 1136
  • [6] MOLECULAR-CLONING, GENOMIC ORGANIZATION, AND CHROMOSOMAL LOCALIZATION OF THE HUMAN PANCREATITIS-ASSOCIATED PROTEIN (PAP) GENE
    DUSETTI, NJ
    FRIGERIO, JM
    FOX, MF
    SWALLOW, DM
    DAGORN, JC
    IOVANNA, JL
    [J]. GENOMICS, 1994, 19 (01) : 108 - 114
  • [7] Frassoldati Antonio, 2005, Clin Breast Cancer, V6, P315, DOI 10.3816/CBC.2005.n.034
  • [8] Prognosis and management of patients with node-negative invasive breast carcinoma that is 1 cm or smaller in size (stage 1; T1a,bNOMO): A review of the literature
    Hanrahan, EO
    Valero, V
    Gonzalez-Angulo, AM
    Hortobagyi, GN
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (13) : 2113 - 2122
  • [9] Human REG I gene is up-regulated in intrahepatic cholangiocarcinoma and its precursor lesions
    Harada, K
    Zen, Y
    Kanemori, Y
    Chen, TC
    Chen, MF
    Yeh, TS
    Jan, YY
    Masuda, S
    Nimura, Y
    Takasawa, S
    Okamoto, H
    Nakanuma, Y
    [J]. HEPATOLOGY, 2001, 33 (05) : 1036 - 1042
  • [10] Kostanová-Poliaková D, 2005, NEOPLASMA, V52, P441