Effective controlled release of captopril by silylation of mesoporous MCM-41

被引：100
作者：
Qu, FY
Zhu, GS [1 ]
Huang, SY
Li, SG
Qiu, SL
机构：
[1] Jilin Univ, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130023, Peoples R China
[2] Jiamusi Univ, Chem & Pharmaceut Coll, Jiamusi 154007, Peoples R China
来源：
CHEMPHYSCHEM | 2006年 / 7卷 / 02期
关键词：
drug delivery; mesoporous materials; silicon; surface chemistry; X-ray diffraction;
D O I：
10.1002/cphc.200500294
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The release of the water-soluble drug Captopril is controlled by tailoring the surface properties of mesoporous silica via stepwise silylation. The degree of silylation is manipulated by adjusting the initial concentration of silylanizing reagent (trimethylchlorosilane, TMCS). The silylanized and drug-loaded samples are characterized by powder X-ray diffraction, Fourier transform IR spectroscopy, N-2 adsorption and desorption, Si-29 cross-polorization magic angle spinning NMR spectroscopy, and transmission electron microscopy. The drug-loading amount is correlated to the Brunauer-Emmett-Teller surface area and surface hydrophilicityl hydrophobicity of the mesoporous silica material, while drug release profiles con be controlled by tailoring the surface properties and pore size.
引用
收藏
页码：400 / 406
页数：7
相关论文
共 36 条
  • [1] Influences of material characteristics on ibuprofen drug loading and release profiles from ordered micro- and mesoporous silica matrices
    Andersson, J
    Rosenholm, J
    Areva, S
    Lindén, M
    [J]. CHEMISTRY OF MATERIALS, 2004, 16 (21) : 4160 - 4167
  • [2] Surface characterization and functionalization of MCM-41 silicas via silazane silylation
    Anwander, R
    Nagl, I
    Widenmeyer, M
    Engelhardt, G
    Groeger, O
    Palm, C
    Röser, T
    [J]. JOURNAL OF PHYSICAL CHEMISTRY B, 2000, 104 (15) : 3532 - 3544
  • [3] Silica particles:: A novel drug-delivery system
    Barbé, C
    Bartlett, J
    Kong, LG
    Finnie, K
    Lin, HQ
    Larkin, M
    Calleja, S
    Bush, A
    Calleja, G
    [J]. ADVANCED MATERIALS, 2004, 16 (21) : 1959 - 1966
  • [4] A NEW FAMILY OF MESOPOROUS MOLECULAR-SIEVES PREPARED WITH LIQUID-CRYSTAL TEMPLATES
    BECK, JS
    VARTULI, JC
    ROTH, WJ
    LEONOWICZ, ME
    KRESGE, CT
    SCHMITT, KD
    CHU, CTW
    OLSON, DH
    SHEPPARD, EW
    MCCULLEN, SB
    HIGGINS, JB
    SCHLENKER, JL
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (27) : 10834 - 10843
  • [5] STUDIES ON MESOPOROUS MATERIALS .1. SYNTHESIS AND CHARACTERIZATION OF MCM-41
    CHEN, CY
    LI, HX
    DAVIS, ME
    [J]. MICROPOROUS MATERIALS, 1993, 2 (01): : 17 - 26
  • [6] Functionalization of SBA-15 with APTES and characterization of functionalized materials
    Chong, ASM
    Zhao, XS
    [J]. JOURNAL OF PHYSICAL CHEMISTRY B, 2003, 107 (46) : 12650 - 12657
  • [7] Mesoporous SBA-15 HPLC evaluation for controlled gentamicin drug delivery
    Doadrio, AL
    Sousa, EMB
    Doadrio, JC
    Pariente, JP
    Izquierdo-Barba, I
    Vallet-Regí, M
    [J]. JOURNAL OF CONTROLLED RELEASE, 2004, 97 (01) : 125 - 132
  • [8] Control of molecular transport through stimuli-responsive ordered mesoporous materials
    Fu, Q
    Rao, GVR
    Ista, LK
    Wu, Y
    Andrzejewski, BP
    Sklar, LA
    Ward, TL
    López, GP
    [J]. ADVANCED MATERIALS, 2003, 15 (15) : 1262 - +
  • [9] Nanocomposite structure based on silylated MCM-48 and poly(vinyl acetate)
    He, J
    Shen, YB
    Yang, J
    Evans, DG
    Duan, X
    [J]. CHEMISTRY OF MATERIALS, 2003, 15 (20) : 3894 - 3902
  • [10] RATE OF RELEASE OF MEDICAMENTS FROM OINTMENT BASES CONTAINING DRUGS IN SUSPENSION
    HIGUCHI, T
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1961, 50 (10) : 874 - &
1234