Progressive multifocal leukoencephalopathy in autoimmune diseases

被引:52
作者
Palazzo, Elisabeth [1 ]
Yahia, Salim Ahmed [1 ]
机构
[1] Hop Bichat Claude Bernard, Serv Rhumatol, F-75018 Paris, France
关键词
Progressive multifocal leukoencephalopathy; Autoimmune disease; Rheumatoid arthritis; Systemic lupus erythematosus; Rituximab; Methotrexate; Leflunomide; SYSTEMIC-LUPUS-ERYTHEMATOSUS; DOSE ORAL METHOTREXATE; RHEUMATIC-DISEASES; B-LYMPHOCYTES; PATIENT; RITUXIMAB; NATALIZUMAB; ARTHRITIS; THERAPY; VIRUS;
D O I
10.1016/j.jbspin.2011.11.002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Progressive multifocal leukoencephalopathy (PML) is a subacute central nervous system infection due to reactivation of the JC virus. Most reported cases occurred in HIV-infected patients (80% of cases), patients with lymphoid malignancies (13%) and transplant recipients taking immunosuppressants (5%). Less often, PML has been described in patients with chronic inflammatory joint diseases associated with autoimmune disorders (lupus, rheumatoid arthritis [RA] and vasculitis) (2%). Magnetic resonance imaging of the brain shows suggestive changes and confirmation of the diagnosis is obtained by performing PCR tests to identify the JC virus in the cerebrospinal fluid or, when necessary, a brain biopsy. No treatments have been proven effective. Most patients experience progressive disease that is fatal within a few months or induces incapacitating neurological impairments. The risk of PML is 0.4/100 000 in patients with RA. In the few case-reports of PML in RA patients, the treatments used included methotrexate (five cases) combined with a biological agent such as infliximab (one case), rituximab (four cases), or leflunomide (two cases including one with concomitant rituximab). PML is an extremely rare but devastating complication. Rituximab therapy is associated with an increased prevalence of PML in RA patients (4/100 000), who should be informed of this risk. In patients with lupus, the risk of PML is higher than in RA (4/100 000) and 40% of cases of PML occur during low-dose glucocorticoid therapy without immunosuppressive therapy. (C) 2011 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:351 / 355
页数:5
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