Effects of PEG Length and Iron Oxide Nanoparticles Size on Reduced Protein Adsorption and Non-Specific Uptake by Macrophage Cells

被引：23

作者：

Ni, Fang ^{[2
]}

Jiang, Li ^{[2
]}

Yang, Ruixia ^{[2
]}

Chen, Zhongping ^{[3
]}

Qi, Xu ^{[1
]}

Wang, Jiwang ^{[1
]}

机构：

[1] Nanjing Med Univ, Dept Resp Med, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Dept Lab Med, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China

[3] Nantong Univ, Inst Naut Med, Nantong 226001, Peoples R China

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2012年 / 12卷 / 03期

关键词：

Magnetic Nanoparticles; Polyethylene Glycol; Mouse Macrophage Cells; MAGNETIC NANOPARTICLES; SURFACE MODIFICATION; INTRACELLULAR UPTAKE; NUCLEIC-ACID; FATTY-ACID; IN-VITRO; CANCER; RESONANCE; NANOCRYSTALS; MICROSPHERES;

D O I：

10.1166/jnn.2012.5753

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

At present, the studies showed that applications of magnetic iron oxide nanoparticels in vivo are hampered by their non-specific uptake by the innate immune system. And surface PEGylation of the nanoparticles maybe a feasible approach to escape from the reticular-endothelial system for a long blood circulation half-life. In this paper, we synthesized two sizes of monodisperse nanoparticles and studied the effects of PEG length on reduced protein adsorption and non-specific uptake by macrophage cells for an ideal material with a relatively long blood half-life. The results show that small nanoparticles with high molecular weight PEGylation may be a more applicable candidate due to their size effect and high efficiency in reducing protein adsorption.

引用

页码：2094 / 2100

页数：7

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