Effects of PEG Length and Iron Oxide Nanoparticles Size on Reduced Protein Adsorption and Non-Specific Uptake by Macrophage Cells

被引：23
作者：
Ni, Fang [2 ]
Jiang, Li [2 ]
Yang, Ruixia [2 ]
Chen, Zhongping [3 ]
Qi, Xu [1 ]
Wang, Jiwang [1 ]
机构：
[1] Nanjing Med Univ, Dept Resp Med, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Dept Lab Med, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China
[3] Nantong Univ, Inst Naut Med, Nantong 226001, Peoples R China
来源：
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2012年 / 12卷 / 03期
关键词：
Magnetic Nanoparticles; Polyethylene Glycol; Mouse Macrophage Cells; MAGNETIC NANOPARTICLES; SURFACE MODIFICATION; INTRACELLULAR UPTAKE; NUCLEIC-ACID; FATTY-ACID; IN-VITRO; CANCER; RESONANCE; NANOCRYSTALS; MICROSPHERES;
D O I：
10.1166/jnn.2012.5753
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
At present, the studies showed that applications of magnetic iron oxide nanoparticels in vivo are hampered by their non-specific uptake by the innate immune system. And surface PEGylation of the nanoparticles maybe a feasible approach to escape from the reticular-endothelial system for a long blood circulation half-life. In this paper, we synthesized two sizes of monodisperse nanoparticles and studied the effects of PEG length on reduced protein adsorption and non-specific uptake by macrophage cells for an ideal material with a relatively long blood half-life. The results show that small nanoparticles with high molecular weight PEGylation may be a more applicable candidate due to their size effect and high efficiency in reducing protein adsorption.
引用
收藏
页码：2094 / 2100
页数：7
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