Anti-inflammatory and antioxidant activities of probiotic powder containing Lactobacillus plantarum 1.2567 in necrotic enteritis model of broiler chickens

被引：21
作者：
Cao, L. [1 ,2 ]
Wu, X. H. [3 ]
Bai, Y. L. [1 ]
Wu, X. Y. [1 ]
Gu, S. B. [1 ]
机构：
[1] Henan Univ Sci & Technol, Coll Food & Bioengn, Luoyang 471023, Henan, Peoples R China
[2] Natl Demonstrat Ctr Expt Food Proc & Safety Educ, Luoyang 471023, Henan, Peoples R China
[3] Henan Univ Sci & Technol, Coll Anim Sci & Technol, Luoyang 471023, Henan, Peoples R China
来源：
LIVESTOCK SCIENCE | 2019年 / 223卷
基金：
中国国家自然科学基金;
关键词：
Lactobacillus; Antioxidant activity; Inflammatory; Broiler chickens; Clostridium perfringens; Necrotic enteritis; CLOSTRIDIUM-PERFRINGENS; GROWTH-PERFORMANCE; NITRIC-OXIDE; INFLAMMATION; SUPPLEMENTATION; TETRASPANINS; SUPEROXIDE; RESISTANCE; IMMUNITY; TOXIN;
D O I：
10.1016/j.livsci.2019.03.009
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Lactobacillus is widely studied for prevention and treatment of intestinal diseases. The study was conducted to determine anti-inflammatory and antioxidative potential of Lactobacillus plantarum 1.2567 using necrotic enteritis (NES) model of broiler chickens caused by Clostridium perfringens. A total of 288 one-day-old broiler chickens were randomly categorized into 4 treatments: CON (basal diet), NES (CON + C. perfringens), LPT (NES + L. plantarum1.2567 powder with skim milk) and SKT (NES + skim milk). Results showed that L. plantarum 1.2567 increased average daily gain of the challenged broiler chickens (P < 0.05), reduced gross lesion scores of the small intestines and ameliorated ileum histopathology (P < 0.05), improved structure of enterocyte microvilli (P < 0.001), attenuated the nitric oxide concentration and myeloperoxidase activity (P < 0.05), reduced the chTNF-alpha and IL-1 beta levels and enhanced the activity of SOD and CAT(P < 0.05), and decreased MDA content (P < 0.05). But skim milk only improved structure of enterocyte microvilli of the challenged broiler chickens (P < 0.05). In conclusion, L. plantarum 1.2567 is a promising tool to control NES by regulating the intestinal mucosal immune response, and improving villi structure and antioxidant defense system in broiler chickens.
引用
收藏
页码：157 / 163
页数：7
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