Modern Surgical Therapy: Limb Salvage and the Role of Amputation for Extremity Soft-Tissue Sarcomas

被引：35

作者：

Ferrone, Marco L. ^{[2
]}

Raut, Chandrajit P. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Ctr Sarcoma & Bone Oncol,Dept Surg,Sch Med, Boston, MA 02115 USA

[2] Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Ctr Sarcoma & Bone Oncol,Dept Orthoped,Sch Med, Boston, MA 02115 USA

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2012年 / 21卷 / 02期

关键词：

Extremity sarcoma; Limb salvage; Radiation therapy; Limb infusion/limb perfusion; TUMOR-NECROSIS-FACTOR; EXTERNAL-BEAM RADIOTHERAPY; FACTOR-ALPHA; RANDOMIZED-TRIAL; POSTOPERATIVE RADIOTHERAPY; ISOLATED PERFUSION; RADIATION-THERAPY; SPARING SURGERY; LOCAL-CONTROL; MELPHALAN;

D O I：

10.1016/j.soc.2011.11.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Historically the surgical management of extremity soft-tissue sarcomas (ESTS) commonly involved amputation. Nowadays limb-sparing, function-preserving surgery is the standard of care for ESTS. Adjuvant therapies such as radiation therapy and chemotherapy are used selectively in an effort to minimize both local recurrence and distant spread. Less common modalities, such as isolated limb perfusion, isolated limb infusion, and hyperthermia are being evaluated to potentially expand the cohort of individuals who may be eligible for limb-sparing surgery and to improve outcomes. This article reviews the standard and evolving approaches to the management of ESTS.

引用

页码：201 / +

页数：14

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