Epibatidine, a nicotinic acetylcholine receptor agonist, inhibits the capsaicin response in dorsal root ganglion neurons

被引：4
|
作者：
Zhang, XF [1 ]
McKenna, DG [1 ]
Briggs, CA [1 ]
机构：
[1] Abbott Labs, Abbott Pk, IL 60064 USA
来源：
BRAIN RESEARCH | 2001年 / 919卷 / 01期
关键词：
nicotinic acetylcholine receptor; vanilloid receptor; dorsal root ganglion; capsaicin; epibatidine; pain;
D O I：
10.1016/S0006-8993(01)03028-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In patch-clamp recordings from small-medium diameter dorsal root ganglion neurons in culture, (+/-)-epibatidine (1 muM) was. able to inhibit the capsaicin response (IC50=0.32 muM) in neurons Where there was no detectable direct nicotinic response. Thus, (+/-)-epibatidine may inhibit the vanilloid receptor in. a manner that is not dependent upon nicotinic current activation, representing another mechanism by which such ligands could modulate vanilloid receptor signaling. (C) 2001 Elsevier Science BY All rights reserved.
引用
收藏
页码：166 / 168
页数：3
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