Epibatidine, a nicotinic acetylcholine receptor agonist, inhibits the capsaicin response in dorsal root ganglion neurons

被引：4
作者：
Zhang, XF [1 ]
McKenna, DG [1 ]
Briggs, CA [1 ]
机构：
[1] Abbott Labs, Abbott Pk, IL 60064 USA
来源：
BRAIN RESEARCH | 2001年 / 919卷 / 01期
关键词：
nicotinic acetylcholine receptor; vanilloid receptor; dorsal root ganglion; capsaicin; epibatidine; pain;
D O I：
10.1016/S0006-8993(01)03028-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In patch-clamp recordings from small-medium diameter dorsal root ganglion neurons in culture, (+/-)-epibatidine (1 muM) was. able to inhibit the capsaicin response (IC50=0.32 muM) in neurons Where there was no detectable direct nicotinic response. Thus, (+/-)-epibatidine may inhibit the vanilloid receptor in. a manner that is not dependent upon nicotinic current activation, representing another mechanism by which such ligands could modulate vanilloid receptor signaling. (C) 2001 Elsevier Science BY All rights reserved.
引用
收藏
页码：166 / 168
页数：3
相关论文
共 50 条
  • [21] Modulation by nitric oxide (NO) of capsaicin-induced calcium uptake into rat dorsal root ganglion neurons
    Park, YH
    Surh, YJ
    Lee, SS
    BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 1999, 47 (03): : 435 - 442
  • [22] Neomycin blocks capsaicin-evoked responses in rat dorsal root ganglion neurons
    Zhou, Y
    Zhou, ZS
    Zhao, ZQ
    NEUROSCIENCE LETTERS, 2001, 315 (1-2) : 98 - 102
  • [23] Presence of α7 nicotinic acetylcholine receptors on dorsal root ganglion neurons proved using knockout mice and selective α-neurotoxins in histochemistry
    Shelukhina, Irina V.
    Kryukova, Elena V.
    Lips, Katrin Susanne
    Tsetlin, Victor I.
    Kummer, Wolfgang
    JOURNAL OF NEUROCHEMISTRY, 2009, 109 (04) : 1087 - 1095
  • [24] Epibatidine binds to four sites on the Torpedo nicotinic acetylcholine receptor
    Kawai, Hideki
    Dunn, Susan M. J.
    Raftery, Michael A.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 366 (03) : 834 - 839
  • [25] Spinorphin inhibits membrane depolarization- and capsaicin-induced intracellular calcium signals in rat primary nociceptive dorsal root ganglion neurons in culture
    Ayar, Ahmet
    Ozcan, Mete
    Kuzgun, Kemal Tugrul
    Kalkan, Omer Faruk
    JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2015, 35 (06) : 550 - 558
  • [26] Effects of Norepinephrine on Galanin Expression in Dorsal Root Ganglion Neurons in Vitro
    Yang, Xiangdong
    Liu, Zhen
    Li, Zhenzhong
    CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 2009, 70 (01): : 19 - 28
  • [27] Celecoxib inhibits Na+ currents in rat dorsal root ganglion neurons
    Park, Soon Yong
    Kim, Tae Hoon
    Kim, Hong Im
    Shin, Yong Kyoo
    Lee, Chung Soo
    Park, Mijung
    Song, Jin-Ho
    BRAIN RESEARCH, 2007, 1148 : 53 - 61
  • [28] The effects of pH on the interaction between capsaicin and the vanilloid receptor in rat dorsal root ganglia neurons
    McLatchie, LM
    Bevan, S
    BRITISH JOURNAL OF PHARMACOLOGY, 2001, 132 (04) : 899 - 908
  • [29] Capsaicin-induced depolarisation of mitochondria in dorsal root ganglion neurons is enhanced by vanilloid receptors
    Dedov, VN
    Mandadi, S
    Armati, PJ
    Verkhratsky, A
    NEUROSCIENCE, 2001, 103 (01) : 219 - 226
  • [30] The nicotinic acetylcholine receptor agonist (±)-epibatidine increases FGF-2 mRNA and protein levels in the rat brain
    Belluardo, N
    Mudò, G
    Blum, M
    Cheng, QZ
    Caniglia, G
    Dell'Albani, P
    Fuxe, K
    MOLECULAR BRAIN RESEARCH, 1999, 74 (1-2): : 98 - 110
12345