Integration of HTLV-1 provirus into mouse transforming growth factor-alpha gene

被引：10

作者：

Fang, JH ^{[1
]}

Kushida, S ^{[1
]}

Feng, RQ ^{[1
]}

Tanaka, M ^{[1
]}

Kikukawa, H ^{[1
]}

Kawamura, T ^{[1
]}

Uchida, K ^{[1
]}

Miwa, M ^{[1
]}

机构：

[1] UNIV TSUKUBA,INST BASIC MED SCI,DEPT BIOCHEM & MOL ONCOL,TSUKUBA,IBARAKI 305,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 233卷 / 03期

关键词：

D O I：

10.1006/bbrc.1997.6557

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human T cell leukemia virus type 1 (HTLV-1) provirus integration was investigated in mice inoculated with MT-2 cells, a HTLV-1 producing human T-cell line, From spleen DNA derived from a MT-2 cell-injected mouse, we cloned a HTLV-1 integration site by ligation-mediated PCR, The nucleotide sequence showed that HTLV-1 provirus was integrated into an intron of the mouse transforming growth factor-cu gene in the reverse orientation. This result provides for the first time molecular evidence that mice can be infected with HTLV-1. (C) 1997 Academic Press.

引用

页码：792 / 795

页数：4

共 23 条

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