Glutamine Synthetase in Legumes: Recent Advances in Enzyme Structure and Functional Genomics

被引：42

作者：

Betti, Marco ^{[1
]}

Garcia-Calderon, Margarita ^{[1
]}

Perez-Delgado, Carmen M. ^{[1
]}

Credali, Alfredo ^{[1
]}

Estivill, Guillermo ^{[1
]}

Galvan, Francisco ^{[1
]}

Vega, Jose M. ^{[1
]}

Marquez, Antonio J. ^{[1
]}

机构：

[1] Univ Seville, Fac Chem, Dept Vegetal Biochem & Mol Biol, Seville 41071, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2012年 / 13卷 / 07期

关键词：

glutamine synthetase; Lotus japonicus; functional genomics; nitrogen metabolism; LOTUS-JAPONICUS DEFICIENT; SITE-DIRECTED MUTAGENESIS; NITROGEN ASSIMILATION; MEDICAGO-TRUNCATULA; ALPHA-POLYPEPTIDE; CO2; ENRICHMENT; POSTTRANSLATIONAL REGULATION; PHOTORESPIRATORY METABOLISM; CRYSTAL-STRUCTURE; 14-3-3; PROTEINS;

D O I：

10.3390/ijms13077994

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glutamine synthetase (GS) is the key enzyme involved in the assimilation of ammonia derived either from nitrate reduction, N-2 fixation, photorespiration or asparagine breakdown. A small gene family is encoding for different cytosolic (GS1) or plastidic (GS2) isoforms in legumes. We summarize here the recent advances carried out concerning the quaternary structure of GS, as well as the functional relationship existing between GS2 and processes such as nodulation, photorespiration and water stress, in this latter case by means of proline production. Functional genomic analysis using GS2-minus mutant reveals the key role of GS2 in the metabolic control of the plants and, more particularly, in carbon metabolism.

引用

页码：7994 / 8024

页数：31

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