Relationship between serum 25-hydroxy vitamin D levels and retinopathy of prematurity

被引：17
|
作者：
Kabatas, Emrah Utku [1 ]
Dinlen, Nurdan Fettah [2 ]
Zenciroglu, Aysegul [2 ]
Dilli, Dilek [2 ]
Beken, Serdar [2 ]
Okumus, Nurullah [2 ]
机构：
[1] Dr Sami Ulus Matern & Children Res & Training Hos, Dept Ophtalmol, TR-06080 Ankara, Turkey
[2] Dr Sami Ulus Matern & Children Res & Training Hos, Dept Neonatol, Ankara, Turkey
来源：
SCOTTISH MEDICAL JOURNAL | 2017年 / 62卷 / 04期
关键词：
Preterm; retinopathy of prematurity; vitamin D; MACULAR DEGENERATION; RISK-FACTORS; D DEFICIENCY; IN-VIVO; ANGIOGENESIS; D-3; CALCITRIOL; CHILDREN; CANCER;
D O I：
10.1177/0036933017701867
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aim: To evaluate the relationship between serum 25-hydroxy vitamin D, 25 (OH) D, levels and retinopathy of prematurity. Methods and Results: Serum 25 (OH) D levels were measured in 97 very low birth weight infants, prior to vitamin D supplementation. The development of retinopathy of prematurity and its treatment requirement were evaluated. At follow-up, retinopathy of prematurity developed in 71 (73.2%) infants. Serum 25 (OH) D levels were significantly lower in infants with retinopathy of prematurity than ones without retinopathy of prematurity (P<0.001). The infants who required treatment had lower 25 (OH) D levels compared with the infants who did not required treatment (7.1 +/- 5.2ng/ml vs. 11.9 +/- 6.5ng/ml; P=0.003). Multivariate analysis showed that lower serum 25 (OH) D levels may be a risk factor for retinopathy of prematurity development [OR: 1.14, 95% CI (1.02-1.27), P=0.02]. Conclusion: Lower 25 (OH) D levels in the first days of life may be related to retinopathy of prematurity development and treatment requirement in premature infants.
引用
收藏
页码：129 / 135
页数：7
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