Frequent evolution of copy number alterations in CLL following first-line treatment with FC(R) is enriched with TP53 alterations: results from the CLL8 trial

被引：16

作者：

Edelmann, J. ^{[1
,2
]}

Tausch, E. ^{[1
]}

Landau, D. A. ^{[3
,4
,5
,6
,7
]}

Robrecht, S. ^{[8
]}

Bahlo, J. ^{[8
]}

Fischer, K. ^{[8
]}

Fink, A. M. ^{[8
]}

Bloehdorn, J. ^{[1
]}

Holzmann, K. ^{[9
]}

Boettcher, S. ^{[10
]}

Werner, L. ^{[11
]}

Kneba, M. ^{[10
]}

Gribben, J. G.

Neuberg, D. S. ^{[11
]}

Wu, C. J. ^{[3
]}

Hallek, M. ^{[8
]}

Doehner, H. ^{[1
]}

Stilgenbauer, S. ^{[1
]}

机构：

[1] Univ Ulm, Internal Med 3, Ulm, Germany

[2] Queen Mary Univ London, Barts Canc Inst, London, England

[3] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[4] Weill Cornell Med, Sandra & Edward Meyer Canc Ctr, New York, NY USA

[5] Weill Cornell Med, Div Hematol & Med Oncol, New York, NY USA

[6] Weill Cornell Med, Dept Physiol & Biophys, New York, NY USA

[7] New York Genome Ctr, New York, NY USA

[8] Univ Cologne, Internal Med 1, Cologne, Germany

[9] Univ Ulm, Clin Res Ctr, Genom Core Facil, Ulm, Germany

[10] Univ Hosp Schleswig Holstein, Dept Med 2, Campus Kiel, Kiel, Germany

[11] Dana Farber Canc Inst, Biostat & Computat Biol, Boston, MA 02115 USA

来源：

LEUKEMIA | 2017年 / 31卷 / 03期

关键词：

CHRONIC LYMPHOCYTIC-LEUKEMIA; CLONAL EVOLUTION; RICHTER SYNDROME; SURVIVAL; TRANSFORMATION; ABERRATIONS; PROGRESSION; MUTATIONS; CANCER;

D O I：

10.1038/leu.2016.317

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：734 / 738

页数：6

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