A role for substance P in arthritis?

被引：56

作者：

Keeble, JE ^{[1
]}

Brain, SD ^{[1
]}

机构：

[1] Kings Coll London, Ctr Cardiovasc Biol & Med, London SE1 1UL, England

来源：

NEUROSCIENCE LETTERS | 2004年 / 361卷 / 1-3期

关键词：

substance P; sensory nerves; neurokinin; 1; receptors; joint; dorsal horn; arthritis;

D O I：

10.1016/j.neulet.2003.12.020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Substance P is a neuropeptide that is released from sensory nerves and which has a number of pro-inflammatory effects. In this article, we review the evidence for a role of substance P in arthritis, both in experimental animal models and rheumatoid arthritis patients. Substance P expression is altered in the joint and dorsal horn of arthritic animals, exogenous substance P and neurokinin 1 (NK1) receptor antagonists modulate responses in the joint, and there is some evidence for a role of substance P in human joint disease. However, the therapeutic potential of NK1 receptor antagonists in the treatment of rheumatoid arthritis remains controversial. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：176 / 179

页数：4

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