Atopic versus infectious diseases in childhood: a question of balance?

被引：244

作者：

Holt, PG ^{[1
]}

Sly, PD ^{[1
]}

Bjorksten, B ^{[1
]}

机构：

[1] LINKOPING UNIV,DEPT PEDIAT,LINKOPING,SWEDEN

来源：

PEDIATRIC ALLERGY AND IMMUNOLOGY | 1997年 / 8卷 / 02期

关键词：

atopy; T-cells; infancy; infection;

D O I：

10.1111/j.1399-3038.1997.tb00145.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

There is an increasing interest in the concept that respiratory tract infections during early childhood may in some circumstances confer protection against sensitisation to aeroallergens, via ''bystander'' stimulation of Th-l associated immune functions in the regional lymph nodes draining the airway mucosa. We hypothesise below that this phenomenon may be but one component of a broader process operative during early postnatal life, in which generalised contact with the microbial environment plays an obligatory role in stimulating the functional maturation of the Th-l arm of the immune response. We argue further that one of the most potent sources of such stimulation is provided by the normal commensal flora of the gastrointestinal tract, which is establish during early infancy.

引用

页码：53 / 58

页数：6

共 43 条

[1] Neonatal and early life immune responses to various forms of vaccine antigens qualitatively differ from adult responses: Predominance of a Th2-biased pattern which persists after adult boosting [J].