Effects of rogue ryanodine receptors on Ca2+ sparks in cardiac myocytes

被引：6

作者：

Chen, Xudong ^{[1
,2
]}

Feng, Yundi ^{[1
,2
]}

Huo, Yunlong ^{[1
,2
,3
]}

Tan, Wenchang ^{[1
,2
,3
,4
]}

机构：

[1] Peking Univ, Coll Engn, State Key Lab Turbulence & Complex Syst, Beijing, Peoples R China

[2] Peking Univ, Coll Engn, Dept Mech & Engn Sci, Beijing, Peoples R China

[3] PKU HKUST Shenzhen Hong Kong Inst, Shenzhen, Peoples R China

[4] Peking Univ, Shenzhen Grad Sch, Shenzhen, Peoples R China

来源：

ROYAL SOCIETY OPEN SCIENCE | 2018年 / 5卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Ca2+ spark; Ca2+ quark; anomalous subdiffusion; rogue ryanodine receptors; CALCIUM SPARKS; LUMINAL CA2+; VENTRICULAR MYOCYTES; HEART-MUSCLE; RELEASE; CELLS; LEAK; DYNAMICS; CHANNELS; MODEL;

D O I：

10.1098/rsos.171462

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ca2+ sparks and Ca2+ quarks, arising from clustered and rogue ryanodine receptors (RyRs), are significant Ca2+ release events from the junctional sarcoplasmic reticulum (JSR). Based on the anomalous subdiffusion of Ca2+ in the cytoplasm, a mathematical model was developed to investigate the effects of rogue RyRs on Ca2+ sparks in cardiac myocytes. Ca2+ quarks and sparks from the stochastic opening of rogue and clustered RyRs are numerically reproduced and agree with experimental measurements. It is found that the stochastic opening Ca2+ release units (CRUs) of clustered RyRs are regulated by free Ca2+ concentration in the JSR lumen (i.e. [Ca2+] lumen). The frequency of spontaneous Ca2+ sparks is remarkably increased by the rogue RyRs opening at high [Ca2+](lumen), but not at low [Ca2+](lumen). Hence, the opening of rogue RyRs contributes to the formation of Ca2+ sparks at high [Ca2+](lumen). The interplay of Ca2+ sparks and Ca2+ quarks has been discussed in detail. This work is of significance to provide insight into understanding Ca2+ release mechanisms in cardiac myocytes.

引用

页数：12

共 42 条

[1]

[Anonymous], 2016, PLOS PATHOG, DOI DOI 10.1016/J.SCIB.2016.12.001)

[2] Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes [J].

Baddeley, David ;

Jayasinghe, Isuru D. ;

Lam, Leo ;

Rossberger, Sabrina ;

Cannell, Mark B. ;

Soeller, Christian .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (52) :22275-22280

[3] Ca channels in cardiac myocytes: structure and function in Ca influx and intracellular Ca release [J].

Bers, DR ;

Perez-Reyes, E .

CARDIOVASCULAR RESEARCH, 1999, 42 (02) :339-360

[4] Quarky Calcium Release in the Heart [J].

Brochet, Didier X. P. ;

Xie, Wenjun ;

Yang, Dongmei ;

Cheng, Heping ;

Lederer, W. Jonathan .

CIRCULATION RESEARCH, 2011, 108 (02) :210-218

[5] Control of Sarcoplasmic Reticulum Ca2+ Release by Stochastic RyR Gating within a 3D Model of the Cardiac Dyad and Importance of Induction Decay for CICR Termination [J].

Cannell, M. B. ;

Kong, C. H. T. ;

Imtiaz, M. S. ;

Laver, D. R. .

BIOPHYSICAL JOURNAL, 2013, 104 (10) :2149-2159

[6] THE CONTROL OF CALCIUM-RELEASE IN HEART-MUSCLE [J].

CANNELL, MB ;

CHENG, H ;

LEDERER, WJ .

SCIENCE, 1995, 268 (5213) :1045-1049

[7] SPATIAL NONUNIFORMITIES IN [CA2+](I) DURING EXCITATION-CONTRACTION COUPLING IN CARDIAC MYOCYTES [J].

CANNELL, MB ;

CHENG, H ;

LEDERER, WJ .

BIOPHYSICAL JOURNAL, 1994, 67 (05) :1942-1956

[8] Calcium waves initiating from the anomalous subdiffusive calcium sparks [J].

Chen, Xi ;

Guo, Liang ;

Kang, Jianhong ;

Huo, Yunlong ;

Wang, Shiqiang ;

Tan, Wenchang .

JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2014, 11 (91)

[9] Modeling Calcium Wave Based on Anomalous Subdiffusion of Calcium Sparks in Cardiac Myocytes [J].

Chen, Xi ;

Kang, Jianhong ;

Fu, Ceji ;

Tan, Wenchang .

PLOS ONE, 2013, 8 (03)

[10] CALCIUM SPARKS - ELEMENTARY EVENTS UNDERLYING EXCITATION-CONTRACTION COUPLING IN HEART-MUSCLE [J].

CHENG, H ;

LEDERER, WJ ;

CANNELL, MB .

SCIENCE, 1993, 262 (5134) :740-744

← 1 2 3 4 5 →