QSAR study of antimycobacterial activity of quaternary ammonium salts of piperidinylethyl esters of alkoxysubstituted phenylcarbamic acids

被引：13

作者：

Waisser, K ^{[1
]}

Dolezal, R

Palát, K

Cizmárik, J

Kaustová, J

机构：

[1] Charles Univ, Fac Pharm, Dept Inorgan & Organ Chem, Hradec Kralove 50005, Czech Republic

[2] Comenius Univ, Fac Pharm, Dept Pharmaceut Sci, Bratislava 83232, Slovakia

[3] Reg Inst Publ Hlth, Dept Diagnost Mycobacteria, Ostrava 70200, Czech Republic

来源：

FOLIA MICROBIOLOGICA | 2006年 / 51卷 / 01期

关键词：

Quaternary Ammonium Salt; Antimycobacterial Activity; Quaternary Salt; Carbamic Acid; Propyl Ester;

D O I：

10.1007/BF02931444

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A series of 17 halogenides of quaternary ammonium salts of the alkylpiperidinylethyl esters of 2-pentoxy (and 2-heptoxy) substituted phenylcarbamic acids were evaluated for in vitro anti mycobacterial activity against Mycobacterium tuberculosis, M. kansasii, and M avium. Correlation of this action with lipophilicity (log P, 1-octanol-water system) was used for the description of the structure-antimycobacterial activity relationships (QSARs). The activity increased with the increasing lipophilicity of the compounds.

引用

页码：21 / 24

页数：4

共 9 条

[1]

Cizmarik J, 1978, Cesk Farm, V27, P427

[2]

CIZMARIK J, 1986, PHARMAZIE, V41, P744

[3] ATOMIC PHYSICOCHEMICAL PARAMETERS FOR 3-DIMENSIONAL STRUCTURE DIRECTED QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS .3. MODELING HYDROPHOBIC INTERACTIONS [J].

GHOSE, AK ;

PRITCHETT, A ;

CRIPPEN, GM .

JOURNAL OF COMPUTATIONAL CHEMISTRY, 1988, 9 (01) :80-90

[4] ω-pyridiniumalkylethers of steroidal phenols:: new compounds with potent antibacterial and antiproliferative activities [J].

Lange, C ;

Holzhey, N ;

Schönecker, B ;

Beckert, R ;

Möllmann, U ;

Dahse, HM .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (12) :3357-3362

[5] A new group of potential antituberculotics:: Hydrochlorides of piperidinylalkyl esters of alkoxy-substituted phenylcarbamic acids [J].

Waisser, K ;

Drazková, K ;

Cizmárik, J ;

Kaustová, J .

FOLIA MICROBIOLOGICA, 2004, 49 (03) :265-268

[6] Antimycobacterial activity of piperidinylpropyl esters of alkoxy-substituted phenylcarbamic acids [J].

Waisser, K ;

Drazková, K ;

Cizmárik, J ;

Kaustová, J .

FOLIA MICROBIOLOGICA, 2003, 48 (05) :585-587

[7]

Waisser K, 2002, Ceska Slov Farm, V51, P140

[8] Antimycobacterial activity of basic ethyl esters of alkoxy-substituted phenylcarbamic acids [J].

Waisser, K ;

Drazková, K ;

Cizmárik, J ;

Kuastová, J .

FOLIA MICROBIOLOGICA, 2003, 48 (01) :45-50

[9]

Waisser K., 2004, SCI PHARM, V72, P43, DOI [10.3797/scipharm.aut-04-05, DOI 10.3797/SCIPHARM.AUT-04-05]

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