Children's Oncology Group's 2013 blueprint for research: Cancer control and supportive care

被引：29

作者：

Sung, Lillian ^{[1
,2
]}

Zaoutis, Theo ^{[3
]}

Ullrich, Nicole J. ^{[4
,5
]}

Johnston, Donna ^{[6
]}

Dupuis, Lee ^{[1
,7
]}

Ladas, Elena ^{[8
]}

机构：

[1] Hosp Sick Children, Dept Haematol Oncol, Toronto, ON M5G 1X8, Canada

[2] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[3] Childrens Hosp Philadelphia, Div Infect Dis, Philadelphia, PA 19104 USA

[4] Boston Childrens Hosp, Dept Neurol, Boston, MA USA

[5] Dana Farber Canc Inst, Boston, MA 02115 USA

[6] Childrens Hosp Eastern Ontario, Dept Hematol Oncol, Ottawa, ON K1H 8L1, Canada

[7] Hosp Sick Children, Dept Pharm, Toronto, ON M5G 1X8, Canada

[8] Columbia Univ, Med Ctr, Dept Pediat Oncol, New York, NY USA

来源：

PEDIATRIC BLOOD & CANCER | 2013年 / 60卷 / 06期

基金：

加拿大健康研究院;

关键词：

cancer control; cognition; infection; supportive care; SCALE CHIMES CHILD; QUALITY-OF-LIFE; PEDIATRIC ONCOLOGY; CONTENT VALIDITY; CHEMOTHERAPY; MORTALITY; MUCOSITIS; OUTCOMES; UNDERSTANDABILITY; METAANALYSIS;

D O I：

10.1002/pbc.24426

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In cancer control research, the objective is to reduce overall morbidity and mortality by decreasing acute and delayed treatment-related toxicities in all children with cancer. To date, the Children's Oncology Group (COG) has focused on infection, neurocognition, quality of life (QoL), and nutrition/antiemetics. COG is conducting randomized controlled trials (RCTs) to determine prophylaxis strategies that will reduce infections in high-risk populations. Two RCTs are determining if modafinil or computerized cognitive training improve cognitive functioning in pediatric brain tumor patients. QoL is being assessed in acute leukemia patients. Improved supportive care outcomes will only occur when the most effective interventions are established. Pediatr Blood Cancer 2013; 60: 10271030. (c) 2012 Wiley Periodicals, Inc.

引用

页码：1027 / 1030

页数：4

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