Isolation and chromosomal mapping of a mouse homolog of the Batten disease gene CLN3

We describe the isolation and chromosomal mapping of a mouse homolog of the Batten disease gene, CLN3, Like its human counterpart, the mouse cDNA contains an open reading frame of 1314 bp encoding a predicted protein product of 438 amino acids, The mouse and human coding regions are 82 and 85% identical at the nucleic acid and amino acid levels, respectively, The mouse gene maps to distal Chromosome 7, in a region containing genes whose homologs are on human chromosome 16p12, where CLN3 maps, Isolation of a mouse CLN3 homolog will facilitate the creation of a mouse model of Batten disease. (C) 1996 Academic Press, Inc.