DIASTEREOSELECTIVE REDUCTIVE AMINATION OF PYRAZOLIDINYL ALKYL KETONES

被引：7

作者：

Sviridova, L. A. ^{[1
]}

Golubeva, G. A. ^{[1
]}

Tavtorkin, A. N. ^{[2
]}

Nelyubina, Yu. V. ^{[2
]}

Kochetkov, K. A. ^{[2
]}

机构：

[1] Moscow MV Lomonosov State Univ, Fac Chem, Moscow 119899, Russia

[2] Russian Acad Sci, AN Nesmeyanov Inst Oganoelement Cpds, Moscow 119991, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2008年 / 44卷 / 05期

关键词：

primary and secondary amines; ketones; pyrazolidines; sodium triacetoxyborohydride; diastereoselective reductive amination;

D O I：

10.1007/s10593-008-0073-x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reductive amination of pyrazolidinyl alkyl ketones with sodium triacetoxyborohydride or sodium tripivaloyloxyborohydride takes place diastereoselectively with the formation of aminoalkyl-pyrazolidines of trans structure. The volume of the substituent in the borohydrides does not affect the ratio of stereoisomers.

引用

页码：542 / 548

页数：7

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