The role of Th17 cells in psoriasis

被引：78

作者：

Li, Binbin ^{[1
,2
]}

Huang, Liangliang ^{[1
]}

Lv, Peng ^{[2
]}

Li, Xiang ^{[1
]}

Liu, Ge ^{[1
]}

Chen, Yan ^{[1
]}

Wang, Ziyu ^{[1
]}

Qian, Xiaoxian ^{[1
]}

Shen, Yixiao ^{[1
]}

Li, Yunman ^{[1
]}

Fang, Weirong ^{[1
]}

机构：

[1] China Pharmaceut Univ, Sch Basic Med Sci & Clin Pharm, State Key Lab Nat Med, Mailbox 207,Tongjiaxiang 24, Nanjing 210009, Jiangsu, Peoples R China

[2] Chia Tai Tianqing Pharmaceut Grp Co Ltd, 1099 Fuying Rd, Nanjing 211122, Jiangsu, Peoples R China

来源：

IMMUNOLOGIC RESEARCH | 2020年 / 68卷 / 05期

关键词：

Th17; cells; Psoriasis; Differentiation; IL-17A; IL-17F; IL-21; IL-22; IL-26; TRANSCRIPTION FACTOR GATA-3; ARYL-HYDROCARBON RECEPTOR; REGULATORY T-CELLS; CUTTING EDGE; GENE-EXPRESSION; TGF-BETA; INDUCIBLE FACTOR; IL-17; PRODUCTION; DENDRITIC CELLS; HELPER-CELLS;

D O I：

10.1007/s12026-020-09149-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T helper 17 (Th17) cells have been involved in the pathogenesis of many autoimmune and inflammatory diseases, like psoriasis, multiple sclerosis (MS), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD). However, the role of Th17 cells in psoriasis has not been clarified completely. Th17-derived proinflammatory cytokines including IL-17A, IL-17F, IL-21, IL-22, and IL-26 have a critical role in the pathogenesis of these disorders. In this review, we introduced the signaling and transcriptional regulation of Th17 cells. And then, we demonstrate the immunopathology role of Th17 cells and functions of the related cytokines in the psoriasis to get a better understanding of the inflammatory mechanisms mediated by Th17 cells in this disease.

引用

页码：296 / 309

页数：14

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