Macropinocytosis and autophagy crosstalk in nutrient scavenging

被引：26

作者：

Florey, Oliver ^{[1
]}

Overholtzer, Michael ^{[2
]}

机构：

[1] Babraham Inst, Signalling Programme, Cambridge CB22 3AT, England

[2] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10065 USA

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2019年 / 374卷 / 1765期

基金：

英国生物技术与生命科学研究理事会;

关键词：

macropinocytosis; autophagy; entosis; phagocytosis; LC3-ASSOCIATED PHAGOCYTOSIS; NONCANONICAL AUTOPHAGY; CELL-DEATH; PROTEIN; GROWTH; METABOLISM; ENTOSIS; LC3; RECEPTOR; KINASE;

D O I：

10.1098/rstb.2018.0154

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Adaptive strategies used by cells to scavenge and recycle essential nutrients are important for survival in nutrient-depleted environments such as cancer tissues. Autophagy and macropinocytosis are two major mechanisms that promote nutrient recycling and scavenging, which share considerable, yet poorly understood, cross-regulation. Here we review recent findings that connect these starvation response mechanisms and discuss the implications of their crosstalk. This article is part of the Theo Murphy meeting issue 'Macropinocytosis'.

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页数：8

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