Suppressive effect of preconditioning low-frequency stimulation on subsequent induction of long-term potentiation by high frequency stimulation in hippocampal CA3 neurons

被引：2

作者：

Yamazaki, Yoshihiko ^{[1
]}

Fujii, Satoshi ^{[1
,3
]}

Goto, Jun-Ichi ^{[1
,3
]}

Sugihara, Toshimichi ^{[1
]}

Sugita, Makoto ^{[1
]}

Fujiwara, Hiroki ^{[1
]}

Kaneko, Kenya ^{[1
]}

Aihara, Takeshi ^{[2
]}

Mikoshiba, Katsuhiko ^{[3
]}

机构：

[1] Yamagata Univ, Sch Med, Dept Physiol, Yamagata 9909585, Japan

[2] Tamagawa Univ, Dept Software Sci, Coll Engn, Machida, Tokyo 1948610, Japan

[3] Riken Brain Sci Inst, Dev Neurobiol Lab, Wako, Saitama 3510198, Japan

来源：

BRAIN RESEARCH | 2012年 / 1449卷

关键词：

Preconditioning; P3; receptor; Mossy-fiber CA3 synapse; LTP induction; LTP suppression; Calcineurin; PROTEIN-KINASE-II; GLUTAMATE RECEPTORS; SYNAPTIC PLASTICITY; MOSSY FIBER-CA3; PHOSPHORYLATION; ACTIVATION; CA2+; LTP; LOCALIZATION; DEPRESSION;

D O I：

10.1016/j.brainres.2012.02.025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the role of inositol 1, 4, 5-trisphosphate receptors (IP3Rs), activated during preconditioning low-frequency afferent stimulation (LFS), in the subsequent induction of long-term potentiation (LTP) in CA3 neurons in hippocampal slices from mature guinea pigs. Induction of LTP in the field excitatory postsynaptic potential (EPSP) by the delivery of high-frequency stimulation (HFS, a tetanus of two trains of 100 pulses at 100 Hz with a 10 s interval) to mossy fiber-CA3 neuron synapses was suppressed when CA3 synapses were preconditioned by the LFS of 1000 pulses at 2 Hz and this effect was inhibited when the LFS preconditioning was performed in the presence of an IP3R antagonist or a protein phosphatase inhibitor. Furthermore, activation of group 1 metabotropic glutamate receptors (mGluRs) during HFS canceled the effects of an IP3R antagonist given during preconditioning LFS on the subsequent LTP induction at mossy fiber-CA3 synapses. These results suggest that, in hippocampal mossy fiber-CA3 neuron synapses, activation of IP3Rs during a preconditioning LFS results in dephosphorylation events that lead to failure of the HFS to induce subsequent LTP. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：15 / 23

页数：9

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