Synthesis of tetra-substituted pyrroles, a potential phosphodiesterase 4B inhibitor, through nickel(II) chloride hexahydrate catalyzed one-pot four-component reaction

被引：77

作者：

Khan, Abu T. ^{[1
]}

Lal, Mohan ^{[1
]}

Bagdi, Prasanta Ray ^{[1
]}

Basha, R. Sidick ^{[1
]}

Saravanan, Parameswaran ^{[2
]}

Patra, Sanjukta ^{[2
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India

[2] Indian Inst Technol Guwahati, Dept Biotechnol, Gauhati 781039, India

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 32期

关键词：

Multicomponent reactions; beta-Ketoesters; Nickel(II) chloride hexahydrate; Tetra-substituted pyrroles; Docking studies; Phosphodiesterase 4B inhibitor; COUPLING REACTION; DERIVATIVES; ALDEHYDES; EFFICIENT; ACTIVATION; AMINES;

D O I：

10.1016/j.tetlet.2012.05.133

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A wide variety of tetra-substituted pyrrole derivatives were synthesized through one-pot four-component condensation reaction of aromatic aldehydes, benzylamines, beta-ketoesters, and nitroalkanes in the presence of 10 mol % NiCl2 center dot 6H(2)O in good yields. Some of them exhibit properties as potential inhibitors of phosphodiesterase 4B (PDE4B) through docking studies. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4145 / 4150

页数：6

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