Iron blocks the accumulation and activity of tetracyclines in bacteria

被引：13

作者：

Avery, AM ^{[1
]}

Goddard, HJ ^{[1
]}

Sumner, ER ^{[1
]}

Avery, SV ^{[1
]}

机构：

[1] Univ Nottingham, Sch Biol, Nottingham NG7 2RD, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 05期

关键词：

D O I：

10.1128/AAC.48.5.1892-1894.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The apparent sensitivities of several bacterial pathogens to tetracyclines varied by up to 128-fold with the medium content of Fe, but not of other metals. The effect of Fe was independent of superoxide dismutase activity and of intracellular Fe, but accumulation of tetracyclines was blocked in high-Fe medium. Thus, synergistic suppression of bacterial growth in the presence of a low Fe concentration and tetracyclines arises because of elevated antibiotic accumulation.

引用

页码：1892 / 1894

页数：3

共 23 条

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