Relationship Between Susceptibility of Candida spp. Isolates to Amphotericin B and Death or Survival of Patients with Candidemia Episodes

被引：2
作者：
Alves, Sydney Hartz [1 ]
Boff, Everton [1 ]
Pozzatti, Patricia [1 ]
Scheid, Liliane A. [1 ]
de Loreto, Erico [1 ]
Ottoneli Oliveira, Loiva T. [2 ]
Aquino, Valerio [3 ]
Severo, Luiz Carlos [4 ]
Santurio, Janio Morais [1 ]
机构：
[1] Univ Fed Santa Maria, Dept Microbiol & Parasitol, BR-97119900 Santa Maria, RS, Brazil
[2] Hosp Univ Santa Maria, Santa Maria, RS, Brazil
[3] Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
[4] Complexo Hosp Santa Casa, Porto Alegre, RS, Brazil
来源：
MYCOPATHOLOGIA | 2009年 / 167卷 / 02期
关键词：
Amphotericin B; Susceptibility tests; Candidemia; Antifungal agents; IN-VITRO SUSCEPTIBILITY; ANTIFUNGAL SUSCEPTIBILITY; INTERPRETIVE BREAKPOINTS; RESISTANT; EPIDEMIOLOGY; SURVEILLANCE; ITRACONAZOLE; MULTICENTER; FLUCONAZOLE; MORTALITY;
D O I：
10.1007/s11046-008-9159-3
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In this study, the susceptibility to amphotericin B of Candida spp. isolates obtained from patients with candidemia was related to their respective clinical outcomes. The susceptibility tests were carried out in three culture media: RPMI 1640, Antibiotic medium 3 and Yeast Nitrogen Base dextrose. We have found that minimal inhibitory concentrations and minimal fungicidal concentrations obtained using AM3 and YNBd media were significantly higher for Candida spp. from patients who died than for those from patients who survived the candidemia (P < 0.05). The assays with RPMI 1640 medium did not show these differences.
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收藏
页码：65 / 71
页数：7
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