Lymphocytic colitis:: a retrospective clinical study of 199 Swedish patients

被引:178
作者
Olesen, M
Eriksson, S
Bohr, J
Järnerot, G
Tysk, C [1 ]
机构
[1] Orebro Univ Hosp, Dept Med, Div Gastroenterol, S-70185 Orebro, Sweden
[2] Orebro Univ Hosp, Dept Pathol, S-70185 Orebro, Sweden
关键词
D O I
10.1136/gut.2003.023440
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Lymphocytic colitis is characterised by chronic diarrhoea and specific microscopic changes in a macroscopically normal colonic mucosa. We report clinical features and treatment outcome in a large patient cohort. Methods: Patients were searched for in 24 Swedish gastroenterology clinics. The biopsy material was reassessed using strict histopathological criteria. Clinical data were obtained from medical notes. Results: Lymphocytic colitis was diagnosed in 199 cases. The female: male ratio was 2.4: 1. Median age at diagnosis was 59 (48 - 70) years. The most frequent symptoms were diarrhoea (96%), abdominal pain (47%), and weight loss (41%). The course was chronic intermittent in 30% of patients, chronic continuous in 7%, and a single attack in 63%, and in these cases the disease duration was 6 ( 4 - 11) months. Seventy nine (40%) patients reported associated diseases, of which thyroid disorders, coeliac disease, and diabetes mellitus were the most common. In 34 first or second degree relatives of 24 (12%) patients, a family history of ulcerative colitis, Crohn's disease, collagenous colitis, or coeliac disease was reported. Drug induced disease was suspected in 19 (10%) patients. A non-significant peak of disease onset was seen in December-January. More than 80% of treated patients improved on corticosteroids, including budesonide. Conclusions: A family history of other bowel disorders is a new finding. The sudden onset and single attack of limited duration may support a possible infectious cause in some cases. Drugs may cause lymphocytic colitis.
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页码:536 / 541
页数:6
相关论文
共 48 条
[1]   Familial microscopic colitis [J].
Abdo, AA ;
Zetler, PJ ;
Halparin, LS .
CANADIAN JOURNAL OF GASTROENTEROLOGY, 2001, 15 (05) :341-343
[2]   Collagenous and lymphocytic colitis in Iceland [J].
Agnarsdottir, M ;
Gunnlaugsson, O ;
Orvar, KB ;
Cariglia, N ;
Birgisson, S ;
Bjornsson, S ;
Thorgeirsson, T ;
Jonasson, JG .
DIGESTIVE DISEASES AND SCIENCES, 2002, 47 (05) :1122-1128
[3]   Prevalence and significance of inflammatory bowel disease-like morphologic features in collagenous and lymphocytic colitis [J].
Ayata, G ;
Ithamukkala, S ;
Sapp, H ;
Shaz, BH ;
Brien, TP ;
Wang, HH ;
Antonioli, DA ;
Farraye, FA ;
Odze, RD .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2002, 26 (11) :1414-1423
[4]   Lymphocytic colitis: a distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis [J].
Baert, F ;
Wouters, K ;
D'Haens, G ;
Hoang, P ;
Naegels, S ;
D'Heygere, F ;
Holvoet, J ;
Louis, E ;
Devos, M ;
Geboes, K .
GUT, 1999, 45 (03) :375-381
[5]   RANITIDINE, DIARRHEA, AND LYMPHOCYTIC COLITIS [J].
BEAUGERIE, L ;
PATEY, N ;
BROUSSE, N .
GUT, 1995, 37 (05) :708-711
[6]   DRUG-INDUCED LYMPHOCYTIC COLITIS [J].
BEAUGERIE, L ;
LUBOINSKI, J ;
BROUSSE, N ;
COSNES, J ;
CHATELET, FP ;
GENDRE, JP ;
LEQUINTREC, Y .
GUT, 1994, 35 (03) :426-428
[7]   Ticlopidine induced colitis: a histopathological study including apoptosis [J].
Berrebi, D ;
Sautet, A ;
Flejou, JF ;
Dauge, MC ;
Peuchmaur, M ;
Potet, F .
JOURNAL OF CLINICAL PATHOLOGY, 1998, 51 (04) :280-283
[8]   Genetic epidemiology in inflammatory bowel disease [J].
Binder, V .
DIGESTIVE DISEASES, 1998, 16 (06) :351-355
[9]   Collagenous colitis: A retrospective study of clinical presentation and treatment in 163 patients [J].
Bohr, J ;
Tysk, C ;
Eriksson, S ;
Abrahamsson, H ;
Jarnerot, G .
GUT, 1996, 39 (06) :846-851
[10]   Collagenous and lymphocytic colitis:: A clinical and histopathological review [J].
Bohr, J ;
Olesen, M ;
Tysk, C ;
Järnerot, G .
CANADIAN JOURNAL OF GASTROENTEROLOGY, 2000, 14 (11) :943-947