Differences in Paclitaxel and Docetaxel Interactions with Tubulin Detected by Mutagenesis of Yeast Tubulin

被引：14

作者：

Winefield, Robert D. ^{[1
]}

Entwistle, Ruth A. ^{[1
]}

Foland, Travis B. ^{[1
]}

Lushington, Gerald H. ^{[2
]}

Himes, Richard H. ^{[1
]}

机构：

[1] Univ Kansas, Dept Mol Biosci, Lawrence, KS 66045 USA

[2] Univ Kansas, Mol Graph & Modeling Lab, Lawrence, KS 66045 USA

来源：

CHEMMEDCHEM | 2008年 / 3卷 / 12期

关键词：

molecular modeling; mutagenesis; taxanes; tubulin; yeast;

D O I：

10.1002/cmdc.200800288

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(Figure Presented) A molecular model showing the yeast tubulin-paclitaxel and tubulin-docetaxel complexes in a mutated form of the protein that contains Asn at position 227 instead of His. The side chain of Asn 227 is able to form an H-bond with the carbonyl oxygen of the paclitaxel benzamide and the docetaxel carbamate groups. © 2008 Wiley-VCH Verlag GmbH& Co. KGaA.

引用

页码：1844 / 1847

页数：4

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