Ruscogenin attenuates monocrotaline-induced pulmonary hypertension in rats

被引：42
作者：
Bi, Li-Qing [1 ,2 ]
Zhu, Rong [3 ]
Kong, Hui [2 ]
Wu, Su-Ling [2 ]
Li, Nan [2 ]
Zuo, Xiang-Rong [4 ]
Zhou, Su-Ming [1 ]
Kou, Jun-Ping [5 ]
Yu, Bo-Yang [6 ]
Wang, Hong [2 ]
Xie, Wei-Ping [2 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Geriatr Intens Care Unit, Nanjing 210029, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Resp Med, Nanjing 210029, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Hosp Huaian 1, Dept Resp Med, Huaian 223300, Peoples R China
[4] Nanjing Med Univ, Affiliated Hosp 1, Dept Intens Care Unit, Nanjing 210029, Jiangsu, Peoples R China
[5] China Pharmaceut Univ, Dept Complex Prescript TCM, Nanjing 211198, Jiangsu, Peoples R China
[6] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 211198, Jiangsu, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2013年 / 16卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Pulmonary hypertension; Ruscogenin; Inflammation; Endothelial dysfunction; RADIX-OPHIOPOGON-JAPONICUS; ACUTE LUNG INJURY; ARTERIAL-HYPERTENSION; NITRIC-OXIDE; NEOINTIMAL FORMATION; AQUEOUS EXTRACT; KAPPA-B; PREVENTS; CELLS; HYDROCHLORIDE;
D O I：
10.1016/j.intimp.2013.03.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Inflammation, endothelial dysfunction, and thrombosis contribute to the pathogenesis and development of human pulmonary arterial hypertension (PAH). The aim of this study was to investigate the effects of ruscogenin, a natural anti-inflammatory and anti-thrombotic agent, on the development of monocrotaline (MCT)-induced PAH in rats. Our results revealed that ruscogenin had favorable effects on hemodynamics and pulmonary vascular remodeling, preventing the development of PAH 3 weeks after MCT. In addition, ruscogenin resulted in markedly reduced expression of inflammatory cytolcine and leukocyte infiltration via the inhibition of nuclear factor (NF)-kappa B activity in rat lungs. Ruscogenin also attenuated MCT-induced endothelial cell apoptosis in the remodeled pulmonary arterioles and rescued destruction of endothelial cell membrane proteins such as eNOS, caveolin-1, and CD31. Our findings suggest that ruscogenin might have therapeutic benefits for PAH patients. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：7 / 16
页数：10
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