High antitumor activity of 5,7-dihalo-8-quinolinolato tin(IV) complexes

被引：34
作者：
Chen, Zhen-Feng [1 ]
Peng, Yan [1 ]
Gu, Yun-Qiong [1 ]
Liu, Yan-Cheng [1 ]
Liu, Mei [1 ]
Huang, Ke-Bin [1 ]
Hu, Kun [1 ]
Liang, Hong [1 ]
机构：
[1] Guangxi Normal Univ, Sch Chem & Chem Engn, State Key Lab Cultivat Base Chem & Mol Engn Med R, Guilin 541004, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 62卷
关键词：
5,7-dihalo-8-quinolinol tin(IV) complex; Crystal structure; Cytotoxicity; DNA binding; IN-VITRO; DNA-BINDING; ALZHEIMERS-DISEASE; CRYSTAL-STRUCTURE; INTERCALATION; RUTHENIUM(II); CYTOTOXICITY; CLIOQUINOL; PROTEASOME; CONJUGATE;
D O I：
10.1016/j.ejmech.2012.12.030
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three tin(IV) complexes [Sn(ClQ)(2)Cl-2] (1), [Sn(BrQ)(2)Cl-2] (2) and [Sn(ClIQ)(2)Cl-2] (3) were prepared (HClQ = 5,7-dichloro-8-hydroxylquinoline, H-BrQ = 5,7-dibromo-8-hydroxylquinoline, H-ClIQ = 5-chloro-7-iodo-8-hydroxylquinoline) and their in vitro cytotoxicities against BEL7404, SKOV-3, NCI-H460, HL-7702 cell lines were evaluated. The complexes showed high anti-proliferative activity toward the tested cell lines with IC50 values ranging from 20 nM to 5.11 mu M. Compared with 5,7-dihalo-8-quinolinol, most complexes exhibited significantly enhanced cytotoxicity (except 2 against SKOV-3 and NCI-H460). They also displayed some selective cytotoxicity favoring the tested tumor cells over the normal human liver HL-7702 cells. Compared with their quinolinol ligands, complexes 1-3 bind more strongly with DNA. Intercalation is the most probable binding mode for both the complexes and their quinolinol ligands. (C) 2012 Elsevier Masson SAS. All rights reserved.
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页码：51 / 58
页数：8
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