Synthesis and Anticancer Activity of 1,3,5-triaryl-1H-pyrazole

被引：20

作者：

Ghadbeigi, Sajad ^{[1
]}

Ostad, Seyed Nasser ^{[3
]}

Shafiee, Abbas ^{[1
]}

Amini, Mohsen ^{[1
,2
]}

机构：

[1] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran, Iran

[2] Univ Tehran Med Sci, Drug Design & Dev Res Ctr, Tehran, Iran

[3] Univ Tehran Med Sci, Fac Pharm, Dept Pharmacol & Toxicol, Tehran, Iran

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2015年 / 12卷 / 09期

关键词：

Tri-arylpyrazole; cytotoxicity; synthesis; HT-29; MCF-7; AGS; CYTOTOXIC EVALUATION; IN-VITRO; AROMATIZATION; DERIVATIVES; ANTITUMOR;

D O I：

10.2174/1570180812666150326004723

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Previous studies demonstrated that some pyrazole derivatives could be considered as potential anticancer agents. A series of 1,3,5-triaryl-1H-pyrazole derivatives were prepared by the reaction of phenylhydrazin and different chalcones. The previous classic synthesis method was developed for a simpler procedure. The cytotoxicity of these compounds was determined against three cancer cell lines (HT-29), (MCF-7), (AGS) as well as fibroblastic cell line (NIH-3T3) using MTT assay. These biological studies proved that 5f and 5l were the most potent compounds in this series. Furthermore, 5f showed a partial selectivity in cytotoxicity effect between the cancerous and normal cell lines.

引用

页码：754 / 759

页数：6

共 20 条

[1]

Abadi AH, 2003, CHEM PHARM BULL, V51, P838

[2] Synthesis, Characterisation, and In Vitro Anticancer Activity of Curcumin Analogues Bearing Pyrazole/Pyrimidine Ring Targeting EGFR Tyrosine Kinase [J].

Ahsan, Mohamed Jawed ;

Khalilullah, Habibullah ;

Yasmin, Sabina ;

Jadav, Surender Singh ;

Govindasamy, Jeyabalan .

BIOMED RESEARCH INTERNATIONAL, 2013, 2013

[3] Design, synthesis, cytotoxic evaluation and tubulin inhibitory activity of 4-aryl-5-(3,4,5-trimethoxyphenyl)-2-alkylthio-1H-imidazole derivatives [J].

Assadieskandar, Amir ;

Amini, Mohsen ;

Ostad, Seyed Nasser ;

Riazi, Gholam Hossein ;

Cheraghi-Shavi, Tayebe ;

Shafiei, Bentolhoda ;

Shafiee, Abbas .

BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (10) :2703-2709

[4] Aromatization of Hantzsch 1,4-dihydropyridines and 1,3,5-trisubstituted pyrazolines with HIO3 and I2O5 in water [J].

Chai, Lingzhi ;

Zhao, Yankai ;

Sheng, Qiuju ;

Liu, Zhong-Quan .

TETRAHEDRON LETTERS, 2006, 47 (52) :9283-9285

[5] REGIOSELECTIVE SYNTHESIS OF 1,3,5-TRISUBSTITUTED PYRAZOLES [J].

Desai, Vidya G. ;

Satardekar, Pooja C. ;

Polo, Sampada ;

Dhumaskar, Kashinath .

SYNTHETIC COMMUNICATIONS, 2012, 42 (06) :836-842

[6] Synthesis and Anticancer Activity of 2,4,5-triaryl Imidazole Derivatives [J].

Elahian, Fatemeh ;

Akbari, Morteza ;

Ghasemi, Maryam ;

Behtooee, Neda ;

Taheri, Mohaddeseh ;

Amini, Mohsen .

LETTERS IN DRUG DESIGN & DISCOVERY, 2014, 11 (07) :840-843

[7]

Ibrahim MM, 2012, JORDAN J CHEM, V7, P115

[8]

Kurt ZK, 2013, LETT DRUG DES DISCOV, V10, P19

[9]

Lauria A, 2014, LETT DRUG DES DISCOV, V11, P15

[10] Synthesis, molecular docking study, and anticancer activity of triaryl-1,2,4-oxadiazole [J].

Miralinaghi, Parisa ;

Salimi, Mona ;

Amirhamzeh, Amirali ;

Norouzi, Mahnaz ;

Kandelousi, Hirsa Mostafapour ;

Shafiee, Abbas ;

Amini, Mohsen .

MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (09) :4253-4262

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