Transcriptional Regulation and Its Misregulation in Disease

被引：1069

作者：

Lee, Tong Ihn ^{[1
]}

Young, Richard A. ^{[1
,2
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

CELL | 2013年 / 152卷 / 06期

基金：

美国国家卫生研究院;

关键词：

RNA-POLYMERASE-II; EMBRYONIC STEM-CELLS; ELONGATION COMPLEX SEC; LINK INTELLECTUAL DISABILITY; CHROMATIN-REMODELING COMPLEX; CONGENITAL HEART-DISEASE; THYMIC EPITHELIAL-CELLS; TERT PROMOTER MUTATIONS; OPITZ-KAVEGGIA-SYNDROME; MIXED LINEAGE LEUKEMIA;

D O I：

10.1016/j.cell.2013.02.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease.

引用

页码：1237 / 1251

页数：15

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