Synchronization Effects in a Metabolism-Driven Model of Multi-cellular System

被引:1
|
作者
Maspero, Davide [1 ,2 ]
Graudenzi, Alex [3 ]
Singh, Satwinder [3 ]
Pescini, Dario [4 ]
Mauri, Giancarlo [3 ]
Antoniotti, Marco [3 ,6 ]
Damiani, Chiara [3 ,5 ]
机构
[1] Univ Milano Bicocca, Dept Biotechnol & Biosci, Milan, Italy
[2] Fdn IRCCS Ist Nazl Tumori, Milan, Italy
[3] Univ Milano Bicocca, Dept Informat Syst & Commun, Milan, Italy
[4] Univ Milano Bicocca, Dept Stat & Quantitat Methods, Milan, Italy
[5] Univ Milano Bicocca, SYSBIO Ctr Syst Biol, Milan, Italy
[6] Univ Milano Bicocca, NeuroMI Milan Ctr Neurosci, Milan, Italy
来源
ARTIFICIAL LIFE AND EVOLUTIONARY COMPUTATION, WIVACE 2018 | 2019年 / 900卷
关键词
Multi-scale modeling; Cellular Potts Model; Flux Balance Analysis; Synchronization; CHEMOSTAT; MECHANISM;
D O I
10.1007/978-3-030-21733-4_9
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
Understanding the synchronization, either induced or spontaneous, of cell growth, division and proliferation in a cell culture is an important topic in molecular biology and biotechnology. Metabolic processes related to the synthesis of all the molecules needed for a new round of cell division are the basic underlying phenomena responsible for the behaviour of the population. Complex dynamics, such as population oscillations, arise when the individual members of a population divide in unison. To investigate the conditions that can determine oscillatory behaviors, we here use a multi-scale model that couples the simulation of metabolic growth, via metabolic network modelling and Flux Balance Analysis, with the simulation of population and spatial dynamics, via Cellular Potts Models. We here show that repeated oscillations in the overall number of cells spontaneously emerge, due to the synchronization of duplication events, unless cell density-dependent controls on growth are introduced.
引用
收藏
页码:115 / 126
页数:12
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