Opportunities for microRNAs in the Crowded Field of Cardiovascular Biomarkers

被引：53
作者：
Halushka, Perry V. [1 ,2 ]
Goodwin, Andrew J. [3 ]
Halushka, Marc K. [4 ]
机构：
[1] Med Univ South Carolina, South Carolina Clin & Translat Res Inst, Dept Pharmacol, Charleston, SC 29425 USA
[2] Med Univ South Carolina, South Carolina Clin & Translat Res Inst, Dept Med, Charleston, SC 29425 USA
[3] Med Univ South Carolina, Div Pulm Crit Care Allergy & Sleep Med, Charleston, SC 29425 USA
[4] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
来源：
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 14 | 2019年 / 14卷
关键词：
microRNAs; biomarkers; cardiovascular disease; hypertension; sepsis; aortic stenosis; CIRCULATING MICRORNAS; HEART-FAILURE; CARDIAC TROPONIN; DIFFERENTIAL EXPRESSION; PREANALYTICAL VARIABLES; DIABETIC CARDIOMYOPATHY; POTENTIAL BIOMARKER; WORKING FORMULATION; ATRIAL-FIBRILLATION; VIRAL MYOCARDITIS;
D O I：
10.1146/annurev-pathmechdis-012418-012827
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Cardiovascular diseases exist across all developed countries. Biomarkers that can predict or diagnose diseases early in their pathogeneses can reduce their morbidity and mortality in afflicted individuals. microRNAs are small regulatory RNAs that modulate translation and have been identified as potential fluid-based biomarkers across numerous maladies. We describe the current state of cardiovascular disease biomarkers across a range of diseases, including myocardial infarction, acute coronary syndrome, myocarditis, hypertension, heart failure, heart transplantation, aortic stenosis, diabetic cardiomyopathy, atrial fibrillation, and sepsis. We present the current understanding of microRNAs as possible biomarkers in these categories and where their best opportunities exist to enter clinical practice.
引用
收藏
页码：211 / 238
页数：28
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