HSV presence in brains of individuals without dementia: the TASTY brain series

被引：33

作者：

Olsson, Jan ^{[1
]}

Lovheim, Hugo ^{[2
]}

Honkala, Emma ^{[1
]}

Karhunen, Pekka J. ^{[3
]}

Elgh, Fredrik ^{[1
]}

Kok, Eloise H. ^{[3
]}

机构：

[1] Umea Univ, Dept Clin Microbiol, Virol, S-90185 Umea, Sweden

[2] Umea Univ, Geriatr Med, Dept Community Med & Rehabil, S-90185 Umea, Sweden

[3] Univ Tampere, Dept Forens Med, Tampere 33520, Finland

来源：

DISEASE MODELS & MECHANISMS | 2016年 / 9卷 / 11期

关键词：

Herpes simplex virus; Amyloid beta aggregations; Alzheimer's disease; PCR detection; Human brain tissue; Paraffin-embedded samples; HERPES-SIMPLEX-VIRUS; POLYMERASE-CHAIN-REACTION; ALZHEIMERS-DISEASE BRAINS; APOLIPOPROTEIN-E GENOTYPE; TYPE-1; DNA; INFLAMMATORY DISEASES; NERVOUS-SYSTEM; INFECTION; RISK; TISSUE;

D O I：

10.1242/dmm.026674

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Herpes simplex virus (HSV) type 1 affects a majority of the population and recent evidence suggests involvement in Alzheimer's disease aetiology. We investigated the prevalence of HSV type 1 and 2 in the Tampere Autopsy Study (TASTY) brain samples using PCR and sero-positivity in plasma, and associations with Alzheimer's disease neuropathology. HSV was shown to be present in human brain tissue in 11/584 (1.9%) of samples in the TASTY cohort, of which six had Alzheimer's disease neuropathological amyloid beta (A beta) aggregations. Additionally, serological data revealed 86% of serum samples tested were IgG-positive for HSV. In conclusion, we report epidemiological evidence of the presence of HSV in brain tissue free from encephalitis symptoms in a cohort most closely representing the general population (a minimum prevalence of 1.9%). Whereas 6/11 samples with HSV DNA in the brain tissue had A beta aggregations, most of those with A beta aggregations did not have HSV present in the brain tissue.

引用

页码：1349 / 1355

页数：7

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