Nuclear phosphoinositide kinases and inositol phospholipids

被引:51
作者
Gonzales, ML [1 ]
Anderson, RA [1 ]
机构
[1] Univ Wisconsin, Dept Pharmacol, Program Mol & Cellular Pharmacol, Sch Med, Madison, WI 53706 USA
关键词
phosphoinositide; diacylglycerol; nucleus; signal transduction; nuclear matrix; phosphoinositide kinase;
D O I
10.1002/jcb.20655
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The presence of inositol phospholipids in the nuclei of mammalian cells has by now been well established, as has the presence of the enzymes responsible for their metabolism. However, our understanding of the role of these nuclear phosphoinositides in regulating cellular events has lagged far behind that for its cytosolic counterpart. It is clear, though, that the nuclear phosphoinositide pool is independent of the cytosolic pool and is, therefore, likely to be regulating a unique set of cellular events. As with its cytosolic phosphoinositides, many nuclear phosphoinositides and their metabolic enzymes are located at distinct sub-cellular structures. This arrangement spatially limits the production and activity of inositol phospholipids and is believed to be a major mechanism for regulating their function. Here, we will introduce the components of nuclear inositol phospholipid signal transduction and discuss how their spatial arrangement may dictate which nuclear functions they are modulating.
引用
收藏
页码:252 / 260
页数:9
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  • [1] Localization of two forms of phospholipase C-β1, a and b, in C6Bu-1 cells
    Bahk, YY
    Song, H
    Baek, SH
    Park, BY
    Kim, H
    Ryu, SH
    Suh, PG
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1998, 1389 (01): : 76 - 80
  • [2] NUCLEAR DIACYLGLYCEROL IS INCREASED DURING CELL-PROLIFERATION INVIVO
    BANFIC, H
    ZIZAK, M
    DIVECHA, N
    IRVINE, RF
    [J]. BIOCHEMICAL JOURNAL, 1993, 290 : 633 - 636
  • [3] Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors
    Boronenkov, IV
    Loijens, JC
    Umeda, M
    Anderson, RA
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (12) : 3547 - 3560
  • [4] Nuclear targeting of the β isoform of Type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its α-helix 7
    Ciruela, A
    Hinchliffe, KA
    Divecha, N
    Irvine, RF
    [J]. BIOCHEMICAL JOURNAL, 2000, 346 (pt 3) : 587 - 591
  • [5] Lipid signalling: Picking out the PIPs
    Clarke, JH
    [J]. CURRENT BIOLOGY, 2003, 13 (20) : R815 - R817
  • [6] Inositol lipids are regulated during cell cycle progression in the nuclei of murine erythroleukaemia cells
    Clarke, JH
    Letcher, AJ
    D'Santos, CS
    Halstead, JR
    Irvine, RF
    Divecha, N
    [J]. BIOCHEMICAL JOURNAL, 2001, 357 (03) : 905 - 910
  • [7] SYNTHESIS OF POLYPHOSPHOINOSITIDES IN NUCLEI OF FRIEND-CELLS - EVIDENCE FOR POLYPHOSPHOINOSITIDE METABOLISM INSIDE THE NUCLEUS WHICH CHANGES WITH CELL-DIFFERENTIATION
    COCCO, L
    GILMOUR, RS
    OGNIBENE, A
    LETCHER, AJ
    MANZOLI, FA
    IRVINE, RF
    [J]. BIOCHEMICAL JOURNAL, 1987, 248 (03) : 765 - 770
  • [8] de Graaf P, 2002, J CELL SCI, V115, P1769
  • [9] SHIP-2 and PTEN are expressed and active in vascular smooth muscle cell nuclei, but only SHIP-2 is associated with nuclear speckles
    Déléris, P
    Bacqueville, D
    Gayral, S
    Carrez, L
    Salles, JP
    Perret, B
    Breton-Douillon, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (40) : 38884 - 38891
  • [10] Phosphatidylinositol 3-kinase C2α contains a nuclear localization sequence and associates with nuclear speckles
    Didichenko, SA
    Thelen, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (51) : 48135 - 48142