Role of Notch signaling pathway in gastric cancer pathogenesis

被引：45
作者：
Brzozowa, Marlena [1 ]
Mielanczyk, Lukasz [1 ]
Michalski, Marek [1 ]
Malinowski, Lukasz [1 ]
Kowalczyk-Ziomek, Grazyna [1 ]
Helewski, Krzysztof [1 ]
Harabin-Slowinska, Marzena [1 ]
Wojnicz, Romuald [1 ]
机构：
[1] Med Univ Silesia, Fac Med & Dent Zabrze, Chair & Dept Histol & Embryol, Katowice, Poland
来源：
WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY | 2013年 / 17卷 / 01期
关键词：
gastric cancer; Notch; miR-34; COX-2; gamma-secretase inhibitors; PROGNOSTIC-FACTOR; COX-2; EXPRESSION; ACTIVATION; CYCLOOXYGENASE-2; PROGRESSION; THERAPY; MIR-34; CELLS; METHYLATION; METASTASIS;
D O I：
10.5114/wo.2013.33765
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Notch signaling pathway is activated dynamically during evolution playing significant role in cell fate determination and differentiation. It has been known that alterations of this pathway may lead to human malignancies, including gastric cancer. Despite a decline in the overall incidence, this disease still remains an important global health problem. Therefore, a better understanding of the molecular alterations underlying gastric cancer may contribute to the development of rationally designed molecular targeted therapies. It has been reported that Notch1 receptor could become a-prognostic marker of gastric cancer and novel target for gastric cancer therapy. Among the novel and targeted approaches for the treatment of gastric cancer is also the process of Notch receptors regulation by specific microRNA. gamma-secretase inhibitors are also taken into consideration.
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收藏
页码：1 / 5
页数：5
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