Anaplastic Lymphoma Kinase Inhibitors for the Treatment of ALK-Positive Cancers

被引:13
作者
Kinoshita, Kazutomo [1 ]
Oikawa, Nobuhiro [1 ]
Tsukuda, Takuo [1 ]
机构
[1] Chugai Pharmaceut Co Ltd, Div Res, Kamakura, Kanagawa, Japan
来源
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 47 | 2012年 / 47卷
关键词
CELL LUNG-CANCER; EXPERIMENTAL-MODELS; ANTITUMOR-ACTIVITY; RESISTANCE; FUSION; POTENT; IDENTIFICATION; CRIZOTINIB; MUTATIONS; PROTEINS;
D O I
10.1016/B978-0-12-396492-2.00019-9
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:281 / 293
页数:13
相关论文
共 44 条
[1]   Development and Scale-Up of an Optimized Route to the ALK Inhibitor CEP-28122 [J].
Allwein, Shawn P. ;
Roemmele, Renee C. ;
Haley, James J., Jr. ;
Mowrey, Dale R. ;
Petrillo, Daniel E. ;
Reif, James J. ;
Gingrich, Diane E. ;
Bakale, Roger P. .
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2012, 16 (01) :148-155
[2]   Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR [J].
Bell, DW ;
Gore, I ;
Okimoto, RA ;
Godin-Heymann, N ;
Sordella, R ;
Mulloy, R ;
Sharma, SV ;
Brannigan, BW ;
Mohapatra, G ;
Settleman, J ;
Haber, DA .
NATURE GENETICS, 2005, 37 (12) :1315-1316
[3]   Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors [J].
Bossi, Roberto T. ;
Saccardo, M. Beatrice ;
Ardini, Elena ;
Menichincheri, Maria ;
Rusconi, Luisa ;
Magnaghi, Paola ;
Orsini, Paolo ;
Avanzi, Nilla ;
Borgia, Andrea Lombardi ;
Nesi, Marcella ;
Bandiera, Tiziano ;
Fogliatto, Gianpaolo ;
Bertrand, Jay A. .
BIOCHEMISTRY, 2010, 49 (32) :6813-6825
[4]   Design, Synthesis, and Anaplastic Lymphoma Kinase (ALK) Inhibitory Activity for a Novel Series of 2,4,8,22-Tetraazatetracyclo[14.3.1.13,7.19,13]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene Macrocycles [J].
Breslin, Henry J. ;
Lane, Brandon M. ;
Ott, Gregory R. ;
Ghose, Arup K. ;
Angeles, Thelma S. ;
Albom, Mark S. ;
Cheng, Mangeng ;
Wan, Weihua ;
Haltiwanger, R. Curtis ;
Wells-Knecht, Kevin J. ;
Dorsey, Bruce D. .
JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (01) :449-464
[5]   Rapid Development of Piperidine Carboxamides as Potent and Selective Anaplastic Lymphoma Kinase Inhibitors [J].
Bryan, Marian C. ;
Whittington, Douglas A. ;
Doherty, Elizabeth M. ;
Falsey, James R. ;
Cheng, Alan C. ;
Emkey, Renee ;
Brake, Rachael L. ;
Lewis, Richard T. .
JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (04) :1698-1705
[6]   Progression-free survival (PFS) from a phase I study of crizotinib (PF-02341066) in patients with ALK-positive non-small cell lung cancer (NSCLC). [J].
Camidge, D. R. ;
Bang, Y. ;
Kwak, E. L. ;
Shaw, A. T. ;
Iafrate, A. J. ;
Maki, R. G. ;
Solomon, B. J. ;
Ou, S. I. ;
Salgia, R. ;
Wilner, K. D. ;
Costa, D. B. ;
Shapiro, G. ;
LoRusso, P. ;
Stephenson, P. ;
Tang, Y. ;
Ruffner, K. ;
Clark, J. W. .
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)
[7]   Glivec (ST1571, Imatinib), a rationally developed, targeted anticancer drug [J].
Capdeville, R ;
Buchdunger, E ;
Zimmermann, J ;
Matter, A .
NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (07) :493-502
[8]   Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity [J].
Chamberlain, Stanley D. ;
Redman, Aniko M. ;
Wilson, Joseph W. ;
Deanda, Felix ;
Shotwell, J. Brad ;
Gerding, Roseanne ;
Lei, Huangshu ;
Yang, Bin ;
Stevens, Kirk L. ;
Hassell, Anne M. ;
Shewchuk, Lisa M. ;
Leesnitzer, M. Anthony ;
Smith, Jeffery L. ;
Sabbatini, Peter ;
Atkins, Charity ;
Groy, Arthur ;
Rowand, Jason L. ;
Kumar, Rakesh ;
Mook, Robert A., Jr. ;
Moorthy, Ganesh ;
Patnaik, Samarjit .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (02) :360-364
[9]   CEP-28122, a Highly Potent and Selective Orally Active Inhibitor of Anaplastic Lymphoma Kinase with Antitumor Activity in Experimental Models of Human Cancers [J].
Cheng, Mangeng ;
Quail, Matthew R. ;
Gingrich, Diane E. ;
Ott, Gregory R. ;
Lu, Lihui ;
Wan, Weihua ;
Albom, Mark S. ;
Angeles, Thelma S. ;
Aimone, Lisa D. ;
Cristofani, Flavio ;
Machiorlatti, Rodolfo ;
Abele, Cristina ;
Ator, Mark A. ;
Dorsey, Bruce D. ;
Inghirami, Giorgio ;
Ruggeri, Bruce A. .
MOLECULAR CANCER THERAPEUTICS, 2012, 11 (03) :670-679
[10]   EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors [J].
Choi, Young Lim ;
Soda, Manabu ;
Yamashita, Yoshihiro ;
Ueno, Toshihide ;
Takashima, Junpei ;
Nakajima, Takahiro ;
Yatabe, Yasushi ;
Takeuchi, Kengo ;
Hamada, Toru ;
Haruta, Hidenori ;
Ishikawa, Yuichi ;
Kimura, Hideki ;
Mitsudomi, Tetsuya ;
Tanio, Yoshiro ;
Mano, Hiroyuki .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (18) :1734-1739