Increased Toll-Like Receptor 2 Expression in Peptidoglycan-Treated Blood Monocytes Is Associated with Insulin Resistance in Patients with Nondiabetic Rheumatoid Arthritis

被引：1

作者：

Wang, Shih-Wei ^{[1
,2
]}

Lin, Tsun-Mei ^{[3
,4
]}

Wang, Chiou-Huey ^{[3
,5
]}

Liu, Hsiao-Han ^{[6
]}

Houng, Jer-Yiing ^{[1
,7
]}

机构：

[1] I Shou Univ, Inst Biotechnol & Chem Engn, Kaohsiung 84001, Taiwan

[2] E DA Hosp, Dept Internal Med, Div Allergy Immunol & Rheumatol, Kaohsiung 82445, Taiwan

[3] E DA Hosp, Dept Lab Med, Kaohsiung 82445, Taiwan

[4] E DA Hosp, Dept Med Res, Kaohsiung 82445, Taiwan

[5] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung 80761, Taiwan

[6] I Shou Univ, Dept Biol Sci & Technol, Kaohsiung 82445, Taiwan

[7] I Shou Univ, Dept Nutr, Kaohsiung 82445, Taiwan

来源：

MEDIATORS OF INFLAMMATION | 2012年 / 2012卷

关键词：

NECROSIS-FACTOR-ALPHA; HOMEOSTASIS MODEL ASSESSMENT; WHITE ADIPOSE-TISSUE; FREE FATTY-ACIDS; MONONUCLEAR PHAGOCYTES; METABOLIC SYNDROME; RISK-FACTORS; INFLAMMATION; GLUCOSE; OBESITY;

D O I：

10.1155/2012/690525

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. Traditional risk factors for metabolic disorders, including the waist circumstance, body mass index (BMI), triglyceride (TG), and ratio of TG to high density lipoprotein (HDL) cholesterol, were closely correlated with HOMA (homoeostasis model assessment) index in patients with nondiabetic RA. Expressions of TLR2 in peripheral blood monocytes, following stimulation with peptidoglycan which is known as a TLR2 agonist, were closely correlated with the HOMA index, TNF-alpha, and IL-6 concentrations. Accordingly, TLR-2 receptor and its related inflammatory cytokines could be potential therapeutic targets in managing insulin resistance in RA patients.

引用

页数：10

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