Expression of amino acid transporters (LAT1, ASCT2 and xCT) as clinical significance in hepatocellular carcinoma

被引：43

作者：

Namikawa, Masashi ^{[1
,7
]}

Kakizaki, Satoru ^{[1
]}

Kaira, Kyoichi ^{[1
,2
]}

Tojima, Hiroki ^{[1
]}

Yamazaki, Yuichi ^{[1
]}

Horiguchi, Norio ^{[1
]}

Sato, Ken ^{[1
]}

Oriuchi, Noboru ^{[3
]}

Tominaga, Hideyuki ^{[6
]}

Sunose, Yutaka ^{[4
]}

Nagamori, Shushi ^{[8
]}

Kanai, Yoshikatsu ^{[8
]}

Oyama, Tetsunari ^{[5
]}

Takeyoshi, Izumi ^{[4
]}

Yamada, Masanobu ^{[1
]}

机构：

[1] Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Gunma, Japan

[2] Gunma Univ, Grad Sch Med, Dept Oncol Clin Dev, Gunma, Japan

[3] Gunma Univ, Grad Sch Med, Dept Diagnost Radiol & Nucl Med, Gunma, Japan

[4] Gunma Univ, Grad Sch Med, Dept Thorac & Visceral Surg, Gunma, Japan

[5] Gunma Univ, Grad Sch Med, Dept Diagnost Pathol, Gunma, Japan

[6] Fukushima Med Univ, Adv Clin Res Ctr, Fukushima, Japan

[7] Kiryu Kosei Gen Hosp, Dept Internal Med, Kiryu, Gunma, Japan

[8] Osaka Univ, Grad Sch Med, Div Biosyst Pharmacol, Osaka, Japan

来源：

HEPATOLOGY RESEARCH | 2015年 / 45卷 / 09期

关键词：

ASCT2; hepatocellular carcinoma; LAT1; prognostic factor; xCT; NONSMALL CELL LUNG; PROGNOSTIC-SIGNIFICANCE; CD98; EXPRESSION; CANCER; CLONING; MARKER;

D O I：

10.1111/hepr.12431

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AimAmino acid transporters play an important role in tumor progression and survival of cancer cells. However, the prognostic significance of L-type amino acid transporter 1 (LAT1), system ASC amino acid transporter-2 (ASCT2) and xCT expression in patients with hepatocellular carcinoma (HCC) remains unclear. The aim of this study is to investigate the clinicopathological significance of these amino acid transporters in patients with HCC. MethodsWe examined 84 patients with surgically resected HCC. Tumor sections were stained by immunohistochemistry for LAT1, ASCT2, xCT, 4F2hc/CD98hc (4F2hc), Ki-67 and microvessel density (MVD) determined by CD34. ResultsLAT1, 4F2hc, ASCT2 and xCT were positively expressed in 61% (50/84), 77% (65/84), 63% (53/84) and 65% (55/84), respectively. Positive LAT1 expression was significantly associated with 4F2hc expression, Ki-67 and the serum albumin. By univariate analysis, LAT1 expression, disease stage and albumin had a significant relationship with overall survival. Tumor size, disease stage, portal vein invasion, albumin and -fetoprotein had a significant relationship with progression-free survival. Multivariate analysis confirmed that LAT1 expression is an independent and significant prognostic factor for predicting worse outcome after surgery. ConclusionLAT1 can serve as a significant prognostic marker for predicting negative prognosis after surgery.

引用

页码：1014 / 1022

页数：9

共 22 条

[1] Exploratory Clinical Trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for Imaging xC Transporter Using Positron Emission Tomography in Patients with Non-Small Cell Lung or Breast Cancer [J].

Baek, Sora ;

Choi, Chang-Min ;

Ahn, Sei Hyun ;

Lee, Jong Won ;

Gong, Gyungyub ;

Ryu, Jin-Sook ;

Oh, Seung Jun ;

Bacher-Stier, Claudia ;

Fels, Lueder ;

Koglin, Norman ;

Hultsch, Christina ;

Schatz, Christoph A. ;

Dinkelborg, Ludger M. ;

Mittra, Erik S. ;

Gambhir, Sanjiv S. ;

Moon, Dae Hyuk .

CLINICAL CANCER RESEARCH, 2012, 18 (19) :5427-5437

[2] Management of hepatoceullular carcinoma [J].

Bruix, J ;

Sherman, M .

HEPATOLOGY, 2005, 42 (05) :1208-1236

[3] CD98 at the crossroads of adaptive immunity and cancer [J].

Cantor, Joseph M. ;

Ginsberg, Mark H. .

JOURNAL OF CELL SCIENCE, 2012, 125 (06) :1373-1382

[4] ROLE OF AMINO-ACID-TRANSPORT AND COUNTERTRANSPORT IN NUTRITION AND METABOLISM [J].

CHRISTENSEN, HN .

PHYSIOLOGICAL REVIEWS, 1990, 70 (01) :43-77

[5] Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime? [J].

Fuchs, BC ;

Bode, BP .

SEMINARS IN CANCER BIOLOGY, 2005, 15 (04) :254-266

[6] Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis [J].

Furuya, Mio ;

Horiguchi, Jun ;

Nakajima, Hiroki ;

Kanai, Yoshikatsu ;

Oyama, Tetsunari .

CANCER SCIENCE, 2012, 103 (02) :382-389

[7] Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance [J].

Huang, Y ;

Dai, ZY ;

Barbacioru, C ;

Sadée, W .

CANCER RESEARCH, 2005, 65 (16) :7446-7454

[8]

Imai H, 2010, ANTICANCER RES, V30, P4819

[9] Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer [J].

Kaira, K. ;

Oriuchi, N. ;

Imai, H. ;

Shimizu, K. ;

Yanagitani, N. ;

Sunaga, N. ;

Hisada, T. ;

Tanaka, S. ;

Ishizuka, T. ;

Kanai, Y. ;

Endou, H. ;

Nakajima, T. ;

Mori, M. .

BRITISH JOURNAL OF CANCER, 2008, 98 (04) :742-748

[10] Prognostic significance of L-type amino-acid transporter 1 expression in surgically resected pancreatic cancer [J].

Kaira, K. ;

Sunose, Y. ;

Arakawa, K. ;

Ogawa, T. ;

Sunaga, N. ;

Shimizu, K. ;

Tominaga, H. ;

Oriuchi, N. ;

Itoh, H. ;

Nagamori, S. ;

Kanai, Y. ;

Segawa, A. ;

Furuya, M. ;

Mori, M. ;

Oyama, T. ;

Takeyoshi, I. .

BRITISH JOURNAL OF CANCER, 2012, 107 (04) :632-638

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