ANTICANCER ACTIVITY OF NEW (TETRAZOL-5-YL)METHYLINDOLE DERIVATIVES AND THEIR ACYCLIC C-NUCLEOSIDE ANALOGS

被引：0
|
作者：
El-Sayed, Wael A. [1 ,3 ]
El-Kosy, Salah M. [2 ]
Ali, Omar M. [2 ]
Emselm, Hadohm M. [2 ]
Abdel-Rahman, Adel A. -H. [2 ,3 ]
机构：
[1] Natl Res Ctr, Dept Photochem, Cairo, Egypt
[2] Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm, Egypt
[3] No Border Univ, Fac Sci, Dept Chem, Ar Ar, Saudi Arabia
来源：
ACTA POLONIAE PHARMACEUTICA | 2012年 / 69卷 / 04期
关键词：
indole; tetrazoles; sugar hydrazones; acyclic nucleosides; anticancer activity; ANTIVIRAL EVALUATION; OXADIAZOLINE DERIVATIVES; CANCER-CELLS; ANTI-HIV; APOPTOSIS; GROWTH; CYCLOOXYGENASE-2; INHIBITION; STRATEGIES; CHEMISTRY;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
New (tetrazol-5-yl)methylindole derivatives were synthesized from 2-phenylindole. Furthermore, the sugar acetyl hydrazones of the tetrazole derivatives as well as their derived acyclic C-nucleoside analogs were prepared. The synthesized compounds were studied for their anticancer activity against human liver carcinoma cell line (HepG2) and the results showed that arylidine substituted tetrazole derivatives 7c and 7d were the most active.
引用
收藏
页码：669 / 677
页数：9
相关论文
共 50 条
  • [21] Novel 2-(1-(substitutedbenzyl)-1H-tetrazol-5-yl)-3-phenylacrylonitrile derivatives: synthesis, in vitro antitumor activity and computational studies
    Maddila, Suresh
    Naicker, Kovashnee
    Momin, Mehbub I. K.
    Rana, Surjyakanta
    Gorle, Sridevi
    Maddila, Suryanarayana
    Yalagala, Kotaiah
    Singh, Moganavelli
    Koorbanally, Neil A.
    Jonnalagadda, Sreekantha B.
    MEDICINAL CHEMISTRY RESEARCH, 2016, 25 (02) : 283 - 291
  • [22] Synthesis and anticancer activity of bis-benzo[d][1,3]dioxol-5-yl thiourea derivatives with molecular docking study
    Al-Harbi, Reem A. K.
    El-Sharief, Marwa A. M. Sh
    Abbas, Samir Y.
    BIOORGANIC CHEMISTRY, 2019, 90
  • [23] Synthesis and Antitumor Activity of New Substituted Mercapto-1,2,4-Triazine Derivatives, Their Thioglycosides, and Acyclic Thioglycoside Analogs
    Nassar, Ibrahim F.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2013, 50 (01) : 129 - 134
  • [24] Synthesis and evaluation of anticancer activity of new 4,5,6,7-tetrabromo-1H-benzimidazole derivatives
    Lukowska-Chojnacka, Edyta
    Fedorov, Egor
    Kowalkowska, Anna
    Wielechowska, Monika
    Sobiepanek, Anna
    Koronkiewicz, Miroslawa
    Winska, Patrycja
    BIOORGANIC CHEMISTRY, 2024, 153
  • [25] Design, Synthesis, and Anticancer Activity of 1,3,4-Oxadiazole Incorporated 5-(Pyrimidin-5-yl)benzo[d]oxazole Derivatives
    Pragathi, Y. J.
    Veronica, D.
    Rao, M. V. Basaveswara
    Raju, R. R.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2020, 90 (12) : 2371 - 2375
  • [26] Design, Synthesis, and Anticancer Activity of 1,3,4-Oxadiazole Incorporated 5-(Pyrimidin-5-yl)benzo[d]oxazole Derivatives
    Y. J. Pragathi
    D. Veronica
    M. V. Basaveswara Rao
    R. R. Raju
    Russian Journal of General Chemistry, 2020, 90 : 2371 - 2375
  • [27] Synthesis, conformational analysis and antimicrobial activity of 10-benzyl-1,2,4-triazolo[4,3-b]1,2,4-triazino[5,6-b]indole acyclo C-nucleoside analogs
    Nasr, Adel Z.
    Keshk, Reda M.
    Abdelrehim, El-Sayed M.
    Sallam, Asmaa S.
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2025, 44 (06) : 433 - 455
  • [28] Novel 2-(1-(substitutedbenzyl)-1H-tetrazol-5-yl)-3-phenylacrylonitrile derivatives: synthesis, in vitro antitumor activity and computational studies
    Suresh Maddila
    Kovashnee Naicker
    Mehbub I. K. Momin
    Surjyakanta Rana
    Sridevi Gorle
    Suryanarayana Maddila
    Kotaiah Yalagala
    Moganavelli Singh
    Neil A. Koorbanally
    Sreekantha B. Jonnalagadda
    Medicinal Chemistry Research, 2016, 25 : 283 - 291
  • [29] Design, synthesis and chemoinformatic studies of new thiazolopyrimidine derivatives as potent anticancer agents via phosphodiesterase-5 inhibition and apoptotic inducing activity
    Nemr, Mohamed T. M.
    Teleb, Mohamed
    AboulMagd, Asmaa M.
    El-Naggar, Mostafa E.
    Gouda, Noha
    Abdel-Ghany, A. A.
    Elshaier, Yaseen A. M. M.
    JOURNAL OF MOLECULAR STRUCTURE, 2023, 1272
  • [30] New N'-Arylidene-2-[(4-Nitrophenyl) Piperazin-1-yl]Acetohydrazide Derivatives: Synthesis and Anticancer Activity Investigation
    Yurttas, Leyla
    Kaplancikli, Zafer A.
    Gorgulu-Kahyaoglu, Sennur
    LETTERS IN DRUG DESIGN & DISCOVERY, 2017, 14 (08) : 910 - 917
12345