ANTICANCER ACTIVITY OF NEW (TETRAZOL-5-YL)METHYLINDOLE DERIVATIVES AND THEIR ACYCLIC C-NUCLEOSIDE ANALOGS

被引：0
|
作者：
El-Sayed, Wael A. [1 ,3 ]
El-Kosy, Salah M. [2 ]
Ali, Omar M. [2 ]
Emselm, Hadohm M. [2 ]
Abdel-Rahman, Adel A. -H. [2 ,3 ]
机构：
[1] Natl Res Ctr, Dept Photochem, Cairo, Egypt
[2] Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm, Egypt
[3] No Border Univ, Fac Sci, Dept Chem, Ar Ar, Saudi Arabia
来源：
ACTA POLONIAE PHARMACEUTICA | 2012年 / 69卷 / 04期
关键词：
indole; tetrazoles; sugar hydrazones; acyclic nucleosides; anticancer activity; ANTIVIRAL EVALUATION; OXADIAZOLINE DERIVATIVES; CANCER-CELLS; ANTI-HIV; APOPTOSIS; GROWTH; CYCLOOXYGENASE-2; INHIBITION; STRATEGIES; CHEMISTRY;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
New (tetrazol-5-yl)methylindole derivatives were synthesized from 2-phenylindole. Furthermore, the sugar acetyl hydrazones of the tetrazole derivatives as well as their derived acyclic C-nucleoside analogs were prepared. The synthesized compounds were studied for their anticancer activity against human liver carcinoma cell line (HepG2) and the results showed that arylidine substituted tetrazole derivatives 7c and 7d were the most active.
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收藏
页码：669 / 677
页数：9
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