Cytotoxic and leishmanicidal properties of garcinielliptone FC, a prenylated benzophenone from Platonia insignis

被引：33

作者：

Costa Junior, Joaquim S. ^{[1
]}

Cardoso de Almeida, Antonia Amanda ^{[2
]}

Falcao Ferraz, Alexandre de Barros ^{[3
]}

Rossatto, Rassa Rebes ^{[3
]}

Silva, Teresinha G. ^{[4
]}

Silva, Paulo B. N. ^{[4
]}

Militao, Gardenia C. G. ^{[5
]}

das Graas Lopes Cito, Antonia Maria ^{[6
]}

Lopes Resende Santana, Lorena Cito ^{[7
]}

de Amorim Carvalho, Fernando Aecio ^{[7
]}

Freitas, Rivelilson M. ^{[2
,7
]}

机构：

[1] Inst Fed Piaui, Dept Quim, BR-64000040 Teresina, PI, Brazil

[2] Univ Fed Piaui, Programa Posgrad Ciencias Farmaceut, BR-64049550 Teresina, PI, Brazil

[3] Univ Luterana Brasil, Programa Posgrad Genet & Toxicol Aplicada, Lab Genet Toxicol, BR-92425900 Canoas, RS, Brazil

[4] Univ Fed Pernambuco, Dept Antibiot, BR-50670901 Recife, PE, Brazil

[5] Univ Fed Pernambuco, Dept Fisiol & Farmacol, BR-50670901 Recife, PE, Brazil

[6] Univ Fed Piaui, Dept Quim, BR-64049550 Teresina, PI, Brazil

[7] Univ Fed Piaui, Dept Bioquim & Farmacol, BR-64049550 Teresina, PI, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 4-5期

关键词：

cytotoxic; garcinielliptone FC; leishmanicidal; Platonia insignis; PHLOROGLUCINOLS; ASSAY;

D O I：

10.1080/14786419.2012.695363

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Garcinielliptone FC (GFC), a natural prenylated benzophenone, was extracted from Platonia insignis Mart. (Clusiaceae), a native plant commonly known as bacuri and used in traditional Brazilian medicine for the treatment of skin diseases. The aim of this study was to evaluate the cytotoxic and leishmanicidal effects of GFC using invitro models. The experimental data demonstrated that the polyisoprenylated benzophenone GFC possesses cytotoxic and leishmanicidal activities.

引用

页码：470 / 474

页数：5

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