Matrix control of transforming growth factor-β function

被引：204

作者：

Horiguchi, Masahito ^{[1
]}

Ota, Mitsuhiko

Rifkin, Daniel B.

机构：

[1] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA

来源：

JOURNAL OF BIOCHEMISTRY | 2012年 / 152卷 / 04期

关键词：

elastic microfibrils; extracellular matrix; integrin; TGF-beta paradox; transforming growth factor-beta; ACTIVATES LATENT TGF-BETA-1; TGF-BETA; EXTRACELLULAR-MATRIX; MEDIATED ACTIVATION; IN-VIVO; BINDING-PROTEINS; LUNG DEVELOPMENT; MOUSE MODEL; LONG FORM; ELASTOGENESIS;

D O I：

10.1093/jb/mvs089

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cytokine transforming growth factor-beta (TGF-beta) has multiple effects in both physiological and pathological conditions. TGF-beta is secreted as part of a tripartite complex from which it must be released in order to bind to its receptor. Sequestration of latent TGF-beta in the extracellular matrix (ECM) is crucial for proper mobilization of the latent cytokine and its activation. However, contrary to expectation, loss-of-function mutations in genes encoding certain matrix proteins that bind TGF-beta yield elevated, rather than decreased, TGF-beta levels, posing a 'TGF-beta paradox.' In this review, we discuss recent findings concerning the relationship of TGF-beta, ECM molecules, and latent TGF-beta activation and propose a model to resolve the 'TGF-beta paradox.'.

引用

页码：321 / 329

页数：9

共 81 条

[1] Impaired liver regeneration in mice by lipopolysaccharide via TNF-α/kallikrein-mediated activation of latent TGF-β [J].

Akita, K ;

Okuno, M ;

Enya, M ;

Imai, S ;

Moriwaki, H ;

Kawada, N ;

Suzuki, Y ;

Kojima, S .

GASTROENTEROLOGY, 2002, 123 (01) :352-364

[2] Stromedix acquisition signals growing interest in fibrosis [J].

Allison, Malorye .

NATURE BIOTECHNOLOGY, 2012, 30 (05) :375-376

[3] Integrin αvβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1 [J].

Annes, JP ;

Chen, Y ;

Munger, JS ;

Rifkin, DB .

JOURNAL OF CELL BIOLOGY, 2004, 165 (05) :723-734

[4] The integrin αVβ6 binds and activates latent TGFβ3 [J].

Annes, JP ;

Rifkin, DB ;

Munger, JS .

FEBS LETTERS, 2002, 511 (1-3) :65-68

[5] Increased expression of integrin αvβ3 contributes to the establishment of autocrine TGF-β signaling in scleroderma fibroblasts [J].

Asano, Y ;

Ihn, H ;

Yamane, K ;

Jinnin, M ;

Mimura, Y ;

Tamaki, K .

JOURNAL OF IMMUNOLOGY, 2005, 175 (11) :7708-7718

[6] Involvement of αVβ5 integrin-mediated activation of latent transforming growth factor β1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts [J].

Asano, Y ;

Ihn, H ;

Yamane, K ;

Jinnin, M ;

Mimura, Y ;

Tamaki, K .

ARTHRITIS AND RHEUMATISM, 2005, 52 (09) :2897-2905

[7] Redox-mediated activation of latent transforming growth factor-beta 1 [J].

BarcellosHoff, MH ;

Dix, TA .

MOLECULAR ENDOCRINOLOGY, 1996, 10 (09) :1077-1083

[8] Transforming growth factor beta (TGF-β) and inflammation in cancer [J].

Bierie, Brian ;

Moses, Harold L. .

CYTOKINE & GROWTH FACTOR REVIEWS, 2010, 21 (01) :49-59

[9] Mechanisms of disease:: Role of transforming growth factor β in human disease. [J].

Blobe, GC ;

Schiemann, WP ;

Lodish, HF .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (18) :1350-1358

[10] Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans [J].

Budatha, Madhusudhan ;

Roshanravan, Shayzreen ;

Zheng, Qian ;

Weislander, Cecilia ;

Chapman, Shelby L. ;

Davis, Elaine C. ;

Starcher, Barry ;

Word, R. Ann ;

Yanagisawa, Hiromi .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (05) :2048-2059

← 1 2 3 4 5 6 7 8 9 →