Matrix control of transforming growth factor-β function

被引：197
作者：
Horiguchi, Masahito [1 ]
Ota, Mitsuhiko
Rifkin, Daniel B.
机构：
[1] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA
来源：
JOURNAL OF BIOCHEMISTRY | 2012年 / 152卷 / 04期
关键词：
elastic microfibrils; extracellular matrix; integrin; TGF-beta paradox; transforming growth factor-beta; ACTIVATES LATENT TGF-BETA-1; TGF-BETA; EXTRACELLULAR-MATRIX; MEDIATED ACTIVATION; IN-VIVO; BINDING-PROTEINS; LUNG DEVELOPMENT; MOUSE MODEL; LONG FORM; ELASTOGENESIS;
D O I：
10.1093/jb/mvs089
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cytokine transforming growth factor-beta (TGF-beta) has multiple effects in both physiological and pathological conditions. TGF-beta is secreted as part of a tripartite complex from which it must be released in order to bind to its receptor. Sequestration of latent TGF-beta in the extracellular matrix (ECM) is crucial for proper mobilization of the latent cytokine and its activation. However, contrary to expectation, loss-of-function mutations in genes encoding certain matrix proteins that bind TGF-beta yield elevated, rather than decreased, TGF-beta levels, posing a 'TGF-beta paradox.' In this review, we discuss recent findings concerning the relationship of TGF-beta, ECM molecules, and latent TGF-beta activation and propose a model to resolve the 'TGF-beta paradox.'.
引用
收藏
页码：321 / 329
页数：9
相关论文
共 81 条
  • [1] Impaired liver regeneration in mice by lipopolysaccharide via TNF-α/kallikrein-mediated activation of latent TGF-β
    Akita, K
    Okuno, M
    Enya, M
    Imai, S
    Moriwaki, H
    Kawada, N
    Suzuki, Y
    Kojima, S
    [J]. GASTROENTEROLOGY, 2002, 123 (01) : 352 - 364
  • [2] Stromedix acquisition signals growing interest in fibrosis
    Allison, Malorye
    [J]. NATURE BIOTECHNOLOGY, 2012, 30 (05) : 375 - 376
  • [3] Integrin αvβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1
    Annes, JP
    Chen, Y
    Munger, JS
    Rifkin, DB
    [J]. JOURNAL OF CELL BIOLOGY, 2004, 165 (05) : 723 - 734
  • [4] The integrin αVβ6 binds and activates latent TGFβ3
    Annes, JP
    Rifkin, DB
    Munger, JS
    [J]. FEBS LETTERS, 2002, 511 (1-3) : 65 - 68
  • [5] Increased expression of integrin αvβ3 contributes to the establishment of autocrine TGF-β signaling in scleroderma fibroblasts
    Asano, Y
    Ihn, H
    Yamane, K
    Jinnin, M
    Mimura, Y
    Tamaki, K
    [J]. JOURNAL OF IMMUNOLOGY, 2005, 175 (11) : 7708 - 7718
  • [6] Involvement of αVβ5 integrin-mediated activation of latent transforming growth factor β1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts
    Asano, Y
    Ihn, H
    Yamane, K
    Jinnin, M
    Mimura, Y
    Tamaki, K
    [J]. ARTHRITIS AND RHEUMATISM, 2005, 52 (09): : 2897 - 2905
  • [7] Redox-mediated activation of latent transforming growth factor-beta 1
    BarcellosHoff, MH
    Dix, TA
    [J]. MOLECULAR ENDOCRINOLOGY, 1996, 10 (09) : 1077 - 1083
  • [8] Transforming growth factor beta (TGF-β) and inflammation in cancer
    Bierie, Brian
    Moses, Harold L.
    [J]. CYTOKINE & GROWTH FACTOR REVIEWS, 2010, 21 (01) : 49 - 59
  • [9] Mechanisms of disease:: Role of transforming growth factor β in human disease.
    Blobe, GC
    Schiemann, WP
    Lodish, HF
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (18) : 1350 - 1358
  • [10] Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans
    Budatha, Madhusudhan
    Roshanravan, Shayzreen
    Zheng, Qian
    Weislander, Cecilia
    Chapman, Shelby L.
    Davis, Elaine C.
    Starcher, Barry
    Word, R. Ann
    Yanagisawa, Hiromi
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (05) : 2048 - 2059
123456789