Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report

被引：8
作者：
Aquino, Gabriella [1 ]
Franco, Renato [1 ]
Ronconi, Fioravante [2 ,4 ]
Anniciello, Annamaria [1 ]
Russo, Luigi [1 ]
De Chiara, Annarosaria [1 ]
Panico, Luigi [3 ]
机构：
[1] Natl Canc Inst Fdn Giovanni Pascale, Pathol Unit, I-80131 Naples, Italy
[2] Hosp SG Moscati, Hematol Unit, I-83100 Avellino, Italy
[3] Hosp SG Moscati, Pathol Unit, I-83100 Avellino, Italy
[4] Hosp Caradarelli, Hematol Unit, Naples, Italy
来源：
DIAGNOSTIC PATHOLOGY | 2012年 / 7卷
关键词：
CCND1 copy gain; Cyclin D1 over-expression; Peripheral T-cell lymphoma; FISH; NON-HODGKINS-LYMPHOMA; IMMUNOHISTOCHEMICAL EXPRESSION; LUNG-CANCER; NECK-CANCER; AMPLIFICATION; CARCINOMA; GENE; CLASSIFICATION; PROTEINS; HEAD;
D O I：
10.1186/1746-1596-7-79
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Peripheral T-cell lymphomas not otherwise specified are generally considered aggressive non-Hodgkin lymphomas, because of poor natural outcome and response to therapy. They show a complex karyotype without any specific genetic hallmark. We report a case of peripheral T-cell lymphoma not otherwise specified with heterogeneous nuclear Cyclin D1 immunohistochemical overexpression, due to gene copy gain, a phenomenon similar to that observed in Mantle Cell Lymphoma characterized by t(11;14)(q13;q32). In this case report we underline the diagnostic pitfall rapresented by Cyclin D1 immunoistochemical overexpression in a T-cell lymphoma. Several pitfalls could lead to misinterpretation of diagnosis, therefore, we underlined the need to integrate the classical histology and immunohistochemistry with molecular tests as clonality or Fluorescence in situ hybridization.
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页数：7
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