Cholesterol and the Safety Factor for Neuromuscular Transmission

被引：46
作者：
Krivoi, Igor I. [1 ]
Petrov, Alexey M. [2 ,3 ]
机构：
[1] St Petersburg State Univ, Dept Gen Physiol, St Petersburg 199034, Russia
[2] Kazan State Med Univ, Inst Neurosci, Butlerova St 49, Kazan 420012, Russia
[3] RAS, Fed Res Ctr, Kazan Sci Ctr, Lab Biophys Synapt Proc,Kazan Inst Biochem & Biop, POB 30,Lobachevsky Str 2-31, Kazan 420111, Russia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 05期
基金：
俄罗斯科学基金会; 俄罗斯基础研究基金会;
关键词：
skeletal muscle; neuromuscular transmission; safety factor; cholesterol and lipid rafts; oxysterols; synaptic vesicle cycle; quantal release; Na; K-ATPase; nicotinic acetylcholine receptor; NICOTINIC ACETYLCHOLINE-RECEPTOR; AMYOTROPHIC-LATERAL-SCLEROSIS; NA-K-ATPASE; MEMBRANE-LIPID RAFTS; RAT SKELETAL-MUSCLE; SYNAPTIC VESICLE; TRANSMITTER RELEASE; PLASMA-MEMBRANE; ACTIVE ZONES; MOUSE MODEL;
D O I：
10.3390/ijms20051046
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A present review is devoted to the analysis of literature data and results of own research. Skeletal muscle neuromuscular junction is specialized to trigger the striated muscle fiber contraction in response to motor neuron activity. The safety factor at the neuromuscular junction strongly depends on a variety of pre- and postsynaptic factors. The review focuses on the crucial role of membrane cholesterol to maintain a high efficiency of neuromuscular transmission. Cholesterol metabolism in the neuromuscular junction, its role in the synaptic vesicle cycle and neurotransmitter release, endplate electrogenesis, as well as contribution of cholesterol to the synaptogenesis, synaptic integrity, and motor disorders are discussed.
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页数：25
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