Imidazolium salts: A mild reducing and antioxidative reagent

被引:69
作者
Zhao, Lan [1 ]
Zhang, Chunyan [1 ]
Zhuo, Lang [1 ]
Zhang, Yugen [1 ]
Ying, Jackie Y. [1 ]
机构
[1] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore
关键词
D O I
10.1021/ja8037883
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The concept of directly using imidazolium salts (IMSs) as mild reducing and antioxidative reagents was proposed and investigated. A simple and robust protocol for the synthesis stable, ultrafine gold nanoparticles has been established using IMSs under mild IMSs showed remarkably lower toxicity but greater antioxidative power than N-acetyl-L-cystein and (-)-epigallocatechin gallate on HSC-T6 cells. These studies demonstrate that the simple and inexpensive IMSs represent a new type of antioxidant with potential biomedical applications.
引用
收藏
页码:12586 / +
页数:3
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共 44 条
[1]   Annulated derivatives of 2,2'-biimidazole, 2-(2'-imidazolyl)benzimidazole, and 2,2'-bibenzimidazole [J].
Ames, JR ;
Houghtaling, MA ;
Terrian, DL ;
Mitchell, TP .
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1997, 75 (01) :28-36
[2]   Formation and stability of N-heterocyclic carbenes in water:: The carbon acid pKa of imidazollum cations in aqueous solution [J].
Amyes, TL ;
Diver, ST ;
Richard, JP ;
Rivas, FM ;
Toth, K .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (13) :4366-4374
[3]   Nanoparticles as recyclable catalysts: The frontier between homogeneous and heterogeneous catalysis [J].
Astruc, D ;
Lu, F ;
Aranzaes, JR .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (48) :7852-7872
[4]   Cationic, linear Au(I) N-heterocyclic carbene complexes:: synthesis, structure and anti-mitochondrial activity [J].
Baker, Murray V. ;
Barnard, Peter J. ;
Berners-Price, Susan J. ;
Brayshaw, Simon K. ;
Hickey, James L. ;
Skelton, Brian W. ;
White, Allan H. .
DALTON TRANSACTIONS, 2006, (30) :3708-3715
[5]   Mitochondrial permeability transition induced by dinuclear gold(I)-carbene complexes: potential new antimitochondrial antitumour agents [J].
Barnard, PJ ;
Baker, MV ;
Berners-Price, SJ ;
Day, DA .
JOURNAL OF INORGANIC BIOCHEMISTRY, 2004, 98 (10) :1642-1647
[6]   SYNTHESIS OF THIOL-DERIVATIZED GOLD NANOPARTICLES IN A 2-PHASE LIQUID-LIQUID SYSTEM [J].
BRUST, M ;
WALKER, M ;
BETHELL, D ;
SCHIFFRIN, DJ ;
WHYMAN, R .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1994, (07) :801-802
[7]   Chiral N-heterocyclic carbenes as stereodirecting ligands in asymmetric catalysis [J].
César, V ;
Bellemin-Laponnaz, S ;
Gade, LH .
CHEMICAL SOCIETY REVIEWS, 2004, 33 (09) :619-636
[8]   Synthesis and structures of 1,3,1′,3′-tetrabenzyl-2,2′-biimidazolidinylidenes (electron-rich alkenes), their aminal intermediates and their degradation products [J].
Çetinkaya, B ;
Çetinkaya, E ;
Chamizo, JA ;
Hitchcock, PB ;
Jasim, HA ;
Küçükbay, H ;
Lappert, MF .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1998, (13) :2047-2054
[9]   Stability and reactivity of N-heterocyclic carbene complexes [J].
Crudden, CM ;
Allen, DP .
COORDINATION CHEMISTRY REVIEWS, 2004, 248 (21-24) :2247-2273
[10]   Gold nanoparticles: Assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology [J].
Daniel, MC ;
Astruc, D .
CHEMICAL REVIEWS, 2004, 104 (01) :293-346